Directed axonal outgrowth using a propagating gradient of IGF-1.
Publication
, Journal Article
Lee, W; Frank, CW; Park, J
Published in: Adv Mater
August 6, 2014
The temporospatial regulation of axon outgrowth is useful for guiding de novo connectivity or re-connectivity of neurons in neurological injury or disease. Here we report the successful construction of a biocompatible guidance device, in which a linear propagation of IGF-1 gradient sequentially directs axon outgrowth. We observe the extensive in vitro axonal extension over 5 mm with a desired growth rate of ∼ 1 mm/day.
Duke Scholars
Published In
Adv Mater
DOI
EISSN
1521-4095
Publication Date
August 6, 2014
Volume
26
Issue
29
Start / End Page
4936 / 4940
Location
Germany
Related Subject Headings
- Polylactic Acid-Polyglycolic Acid Copolymer
- Polyglycolic Acid
- Nanoscience & Nanotechnology
- Motor Neurons
- Lactic Acid
- Insulin-Like Growth Factor I
- Humans
- Drug Liberation
- Drug Carriers
- Axons
Citation
APA
Chicago
ICMJE
MLA
NLM
Lee, W., Frank, C. W., & Park, J. (2014). Directed axonal outgrowth using a propagating gradient of IGF-1. Adv Mater, 26(29), 4936–4940. https://doi.org/10.1002/adma.201305995
Lee, Wonjae, Curtis W. Frank, and Jon Park. “Directed axonal outgrowth using a propagating gradient of IGF-1.” Adv Mater 26, no. 29 (August 6, 2014): 4936–40. https://doi.org/10.1002/adma.201305995.
Lee W, Frank CW, Park J. Directed axonal outgrowth using a propagating gradient of IGF-1. Adv Mater. 2014 Aug 6;26(29):4936–40.
Lee, Wonjae, et al. “Directed axonal outgrowth using a propagating gradient of IGF-1.” Adv Mater, vol. 26, no. 29, Aug. 2014, pp. 4936–40. Pubmed, doi:10.1002/adma.201305995.
Lee W, Frank CW, Park J. Directed axonal outgrowth using a propagating gradient of IGF-1. Adv Mater. 2014 Aug 6;26(29):4936–4940.
Published In
Adv Mater
DOI
EISSN
1521-4095
Publication Date
August 6, 2014
Volume
26
Issue
29
Start / End Page
4936 / 4940
Location
Germany
Related Subject Headings
- Polylactic Acid-Polyglycolic Acid Copolymer
- Polyglycolic Acid
- Nanoscience & Nanotechnology
- Motor Neurons
- Lactic Acid
- Insulin-Like Growth Factor I
- Humans
- Drug Liberation
- Drug Carriers
- Axons