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Phylogeny, ecology and taxonomy of systemic pathogens and their relatives in Ajellomycetaceae (Onygenales): Blastomyces, Emergomyces, Emmonsia, Emmonsiellopsis

Publication ,  Journal Article
Jiang, Y; Dukik, K; Muñoz, JF; Sigler, L; Schwartz, IS; Govender, NP; Kenyon, C; Feng, P; van den Ende, BG; Stielow, JB; Stchigel, AM; Lu, H ...
Published in: Fungal Diversity
May 1, 2018

The family Ajellomycetaceae (Onygenales) includes mammal-associated pathogens within the genera Blastomyces, Emmonsia, Histoplasma and Paracoccidioides, as well as the recently described genera, Emergomyces that causes disease in immunocompromised hosts, and Emmonsiellopsis, known only from soil. To further assess the phylogenetic relationships among and between members of these genera and several previously undescribed species, we sequenced and analyzed the DNA-directed RNA polymerase II (rPB2), translation elongation factor 3-α (TEF3), β-tubulin (TUB2), 28S large subunit rDNA (LSU) and the internal transcribed spacer regions (ITS) in 68 strains, in addition to morphological and physiological investigations. To better understand the thermal dimorphism among these fungi, the dynamic process of transformation from mycelial to yeast-like or adiaspore-like forms was also assessed over a range of temperatures (6–42 °C). Molecular data resolved the relationships and recognized five major well-supported lineages that correspond largely to the genus level. Emmonsia, typified by Emmonsia parva, is a synonym of Blastomyces that also accommodates Blastomyces helicus (formerly Emmonsia helica). Emmonsia crescens is phylogenetically distinct, and found closely related to a single strain from soil without known etiology. Blastomyces silverae, Emergomyces canadensis, Emergomyces europaeus and Emmonsia sola are newly described. Almost all of the taxa are associated with human and animal disease. Emmonsia crescens, B. dermatitidis and B. parvus are prevalently associated with pulmonary disease in humans or animals. Blastomyces helicus, B. percursus, Emergomyces africanus, Es. canadensis, Es. europaeus, Es. orientalis and Es. pasteurianus (formerly Emmonsia pasteuriana) are predominantly found in human hosts with immune disorders; no animal hosts are known for these species except B. helicus.

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Published In

Fungal Diversity

DOI

EISSN

1878-9129

ISSN

1560-2745

Publication Date

May 1, 2018

Volume

90

Issue

1

Start / End Page

245 / 291

Related Subject Headings

  • Mycology & Parasitology
  • 3108 Plant biology
  • 3107 Microbiology
  • 3104 Evolutionary biology
  • 0607 Plant Biology
  • 0605 Microbiology
  • 0603 Evolutionary Biology
 

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Jiang, Y., Dukik, K., Muñoz, J. F., Sigler, L., Schwartz, I. S., Govender, N. P., … de Hoog, S. (2018). Phylogeny, ecology and taxonomy of systemic pathogens and their relatives in Ajellomycetaceae (Onygenales): Blastomyces, Emergomyces, Emmonsia, Emmonsiellopsis. Fungal Diversity, 90(1), 245–291. https://doi.org/10.1007/s13225-018-0403-y
Jiang, Y., K. Dukik, J. F. Muñoz, L. Sigler, I. S. Schwartz, N. P. Govender, C. Kenyon, et al. “Phylogeny, ecology and taxonomy of systemic pathogens and their relatives in Ajellomycetaceae (Onygenales): Blastomyces, Emergomyces, Emmonsia, Emmonsiellopsis.” Fungal Diversity 90, no. 1 (May 1, 2018): 245–91. https://doi.org/10.1007/s13225-018-0403-y.
Jiang Y, Dukik K, Muñoz JF, Sigler L, Schwartz IS, Govender NP, et al. Phylogeny, ecology and taxonomy of systemic pathogens and their relatives in Ajellomycetaceae (Onygenales): Blastomyces, Emergomyces, Emmonsia, Emmonsiellopsis. Fungal Diversity. 2018 May 1;90(1):245–91.
Jiang, Y., et al. “Phylogeny, ecology and taxonomy of systemic pathogens and their relatives in Ajellomycetaceae (Onygenales): Blastomyces, Emergomyces, Emmonsia, Emmonsiellopsis.” Fungal Diversity, vol. 90, no. 1, May 2018, pp. 245–91. Scopus, doi:10.1007/s13225-018-0403-y.
Jiang Y, Dukik K, Muñoz JF, Sigler L, Schwartz IS, Govender NP, Kenyon C, Feng P, van den Ende BG, Stielow JB, Stchigel AM, Lu H, de Hoog S. Phylogeny, ecology and taxonomy of systemic pathogens and their relatives in Ajellomycetaceae (Onygenales): Blastomyces, Emergomyces, Emmonsia, Emmonsiellopsis. Fungal Diversity. 2018 May 1;90(1):245–291.
Journal cover image

Published In

Fungal Diversity

DOI

EISSN

1878-9129

ISSN

1560-2745

Publication Date

May 1, 2018

Volume

90

Issue

1

Start / End Page

245 / 291

Related Subject Headings

  • Mycology & Parasitology
  • 3108 Plant biology
  • 3107 Microbiology
  • 3104 Evolutionary biology
  • 0607 Plant Biology
  • 0605 Microbiology
  • 0603 Evolutionary Biology