Variability of Hydroxy-Itraconazole in Relation to Itraconazole Bloodstream Concentrations.
Publication
, Journal Article
Wiederhold, NP; Schwartz, IS; Patterson, TF; Thompson, GR
Published in: Antimicrob Agents Chemother
March 18, 2021
We analyzed the relationship between itraconazole (ITZ) and hydroxy-itraconazole (OH-ITZ) levels in 1,223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (Pearson's r, 0.7838), and OH-ITZ levels were generally higher than ITZ levels (median OH-ITZ:ITZ ratio, 1.73; range, 0.13 to 8.96). However, marked variability was observed throughout the range of ITZ concentrations. Thus, it is difficult to predict OH-ITZ concentrations based solely on ITZ levels.
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Published In
Antimicrob Agents Chemother
DOI
EISSN
1098-6596
Publication Date
March 18, 2021
Volume
65
Issue
4
Location
United States
Related Subject Headings
- Microbiology
- Itraconazole
- Humans
- Antifungal Agents
- 3214 Pharmacology and pharmaceutical sciences
- 3207 Medical microbiology
- 3107 Microbiology
- 1115 Pharmacology and Pharmaceutical Sciences
- 1108 Medical Microbiology
- 0605 Microbiology
Citation
APA
Chicago
ICMJE
MLA
NLM
Wiederhold, N. P., Schwartz, I. S., Patterson, T. F., & Thompson, G. R. (2021). Variability of Hydroxy-Itraconazole in Relation to Itraconazole Bloodstream Concentrations. Antimicrob Agents Chemother, 65(4). https://doi.org/10.1128/AAC.02353-20
Wiederhold, Nathan P., Ilan S. Schwartz, Thomas F. Patterson, and George R. Thompson. “Variability of Hydroxy-Itraconazole in Relation to Itraconazole Bloodstream Concentrations.” Antimicrob Agents Chemother 65, no. 4 (March 18, 2021). https://doi.org/10.1128/AAC.02353-20.
Wiederhold NP, Schwartz IS, Patterson TF, Thompson GR. Variability of Hydroxy-Itraconazole in Relation to Itraconazole Bloodstream Concentrations. Antimicrob Agents Chemother. 2021 Mar 18;65(4).
Wiederhold, Nathan P., et al. “Variability of Hydroxy-Itraconazole in Relation to Itraconazole Bloodstream Concentrations.” Antimicrob Agents Chemother, vol. 65, no. 4, Mar. 2021. Pubmed, doi:10.1128/AAC.02353-20.
Wiederhold NP, Schwartz IS, Patterson TF, Thompson GR. Variability of Hydroxy-Itraconazole in Relation to Itraconazole Bloodstream Concentrations. Antimicrob Agents Chemother. 2021 Mar 18;65(4).
Published In
Antimicrob Agents Chemother
DOI
EISSN
1098-6596
Publication Date
March 18, 2021
Volume
65
Issue
4
Location
United States
Related Subject Headings
- Microbiology
- Itraconazole
- Humans
- Antifungal Agents
- 3214 Pharmacology and pharmaceutical sciences
- 3207 Medical microbiology
- 3107 Microbiology
- 1115 Pharmacology and Pharmaceutical Sciences
- 1108 Medical Microbiology
- 0605 Microbiology