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Suture, synthetic, or biologic in contaminated ventral hernia repair.

Publication ,  Journal Article
Bondre, IL; Holihan, JL; Askenasy, EP; Greenberg, JA; Keith, JN; Martindale, RG; Roth, JS; Liang, MK; Ventral Hernia Outcomes Collaborative,
Published in: J Surg Res
February 2016

BACKGROUND: Data are lacking to support the choice between suture, synthetic mesh, or biologic matrix in contaminated ventral hernia repair (VHR). We hypothesize that in contaminated VHR, suture repair is associated with the lowest rate of surgical site infection (SSI). METHODS: A multicenter database of all open VHR performed at from 2010-2011 was reviewed. All patients with follow-up of 1 mo and longer were included. The primary outcome was SSI as defined by the Centers for Disease Control and Prevention. The secondary outcome was hernia recurrence (assessed clinically or radiographically). Multivariate analysis (stepwise regression for SSI and Cox proportional hazard model for recurrence) was performed. RESULTS: A total of 761 VHR were reviewed for a median (range) follow-up of 15 (1-50) mo: there were 291(38%) suture, 303 (40%) low-density and/or mid-density synthetic mesh, and 167(22%) biologic matrix repair. On univariate analysis, there were differences in the three groups including ethnicity, ASA, body mass index, institution, diabetes, primary versus incisional hernia, wound class, hernia size, prior VHR, fascial release, skin flaps, and acute repair. The unadjusted outcomes for SSI (15.1%; 17.8%; 21.0%; P = 0.280) and recurrence (17.8%; 13.5%; 21.5%; P = 0.074) were not statistically different between groups. On multivariate analysis, biologic matrix was associated with a nonsignificant reduction in both SSI and recurrences, whereas synthetic mesh associated with fewer recurrences compared to suture (hazard ratio = 0.60; P = 0.015) and nonsignificant increase in SSI. CONCLUSIONS: Interval estimates favored biologic matrix repair in contaminated VHR; however, these results were not statistically significant. In the absence of higher level evidence, surgeons should carefully balance risk, cost, and benefits in managing contaminated ventral hernia repair.

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Published In

J Surg Res

DOI

EISSN

1095-8673

Publication Date

February 2016

Volume

200

Issue

2

Start / End Page

488 / 494

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Sutures
  • Surgical Wound Infection
  • Surgical Mesh
  • Surgery
  • Retrospective Studies
  • Recurrence
  • Proportional Hazards Models
  • Practice Patterns, Physicians'
 

Citation

APA
Chicago
ICMJE
MLA
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Bondre, I. L., Holihan, J. L., Askenasy, E. P., Greenberg, J. A., Keith, J. N., Martindale, R. G., … Ventral Hernia Outcomes Collaborative, . (2016). Suture, synthetic, or biologic in contaminated ventral hernia repair. J Surg Res, 200(2), 488–494. https://doi.org/10.1016/j.jss.2015.09.007
Bondre, Ioana L., Julie L. Holihan, Erik P. Askenasy, Jacob A. Greenberg, Jerrod N. Keith, Robert G. Martindale, J Scott Roth, Mike K. Liang, and Mike K. Ventral Hernia Outcomes Collaborative. “Suture, synthetic, or biologic in contaminated ventral hernia repair.J Surg Res 200, no. 2 (February 2016): 488–94. https://doi.org/10.1016/j.jss.2015.09.007.
Bondre IL, Holihan JL, Askenasy EP, Greenberg JA, Keith JN, Martindale RG, et al. Suture, synthetic, or biologic in contaminated ventral hernia repair. J Surg Res. 2016 Feb;200(2):488–94.
Bondre, Ioana L., et al. “Suture, synthetic, or biologic in contaminated ventral hernia repair.J Surg Res, vol. 200, no. 2, Feb. 2016, pp. 488–94. Pubmed, doi:10.1016/j.jss.2015.09.007.
Bondre IL, Holihan JL, Askenasy EP, Greenberg JA, Keith JN, Martindale RG, Roth JS, Liang MK, Ventral Hernia Outcomes Collaborative. Suture, synthetic, or biologic in contaminated ventral hernia repair. J Surg Res. 2016 Feb;200(2):488–494.
Journal cover image

Published In

J Surg Res

DOI

EISSN

1095-8673

Publication Date

February 2016

Volume

200

Issue

2

Start / End Page

488 / 494

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Sutures
  • Surgical Wound Infection
  • Surgical Mesh
  • Surgery
  • Retrospective Studies
  • Recurrence
  • Proportional Hazards Models
  • Practice Patterns, Physicians'