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Using Interleukin 6 and 8 in Blood and Bronchoalveolar Lavage Fluid to Predict Survival in Hematological Malignancy Patients With Suspected Pulmonary Mold Infection.

Publication ,  Journal Article
Rawlings, SA; Heldt, S; Prattes, J; Eigl, S; Jenks, JD; Flick, H; Rabensteiner, J; Prüller, F; Wölfler, A; Neumeister, P; Strohmaier, H ...
Published in: Front Immunol
2019

Background: Molds and other pathogens induce elevated levels of several cytokines, including interleukin (IL)-6 and IL-8. The objective of this study was to investigate the prognostic value of IL-6 and IL-8 as well as fungal biomarkers in blood and bronchoalveolar lavage fluid (BAL) for overall survival in patients with underlying hematological malignancies and suspected mold infection. Methods: This cohort study included 106 prospectively enrolled adult cases undergoing bronchoscopy. Blood samples were collected within 24 h of BAL sampling and, in a subset of 62 patients, serial blood samples were collected up until 4 days after bronchoscopy. IL-6, IL-8, and other cytokines as well as galactomannan (GM) and β-D-glucan (BDG) were assayed in blood and BAL fluid and associations with overall mortality were assessed at the end of the study using receiver operating characteristic (ROC) curve analysis. Results: Both blood IL-8 (AUC 0.731) and blood IL-6 (AUC 0.699) as well as BAL IL-6 (AUC 0.763) and BAL IL-8 (AUC 0.700) levels at the time of bronchoscopy were predictors of 30-day all-cause mortality. Increasing blood IL-6 levels between bronchoscopy and day four after bronchoscopy were significantly associated with higher 90-day mortality, with similar findings for increasing IL-8 levels. In ROC analysis the difference of blood IL-8 levels between 4 days after bronchoscopy and the day of bronchoscopy had an AUC of 0.829 (95%CI 0.71-0.95; p < 0.001) for predicting 90-day mortality. Conclusions: Elevated levels of IL-6 and IL-8 in blood or BAL fluid at the time of bronchoscopy, and rising levels in blood 4 days following bronchoscopy were predictive of mortality in these patients with underlying hematological malignancy who underwent bronchoscopy for suspected mold infection.

Duke Scholars

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Published In

Front Immunol

DOI

EISSN

1664-3224

Publication Date

2019

Volume

10

Start / End Page

1798

Location

Switzerland

Related Subject Headings

  • Respiratory Tract Infections
  • ROC Curve
  • Prospective Studies
  • Middle Aged
  • Mannans
  • Male
  • Interleukin-8
  • Interleukin-6
  • Humans
  • Hematologic Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rawlings, S. A., Heldt, S., Prattes, J., Eigl, S., Jenks, J. D., Flick, H., … Hoenigl, M. (2019). Using Interleukin 6 and 8 in Blood and Bronchoalveolar Lavage Fluid to Predict Survival in Hematological Malignancy Patients With Suspected Pulmonary Mold Infection. Front Immunol, 10, 1798. https://doi.org/10.3389/fimmu.2019.01798
Rawlings, Stephen A., Sven Heldt, Juergen Prattes, Susanne Eigl, Jeffrey D. Jenks, Holger Flick, Jasmin Rabensteiner, et al. “Using Interleukin 6 and 8 in Blood and Bronchoalveolar Lavage Fluid to Predict Survival in Hematological Malignancy Patients With Suspected Pulmonary Mold Infection.Front Immunol 10 (2019): 1798. https://doi.org/10.3389/fimmu.2019.01798.
Rawlings, Stephen A., et al. “Using Interleukin 6 and 8 in Blood and Bronchoalveolar Lavage Fluid to Predict Survival in Hematological Malignancy Patients With Suspected Pulmonary Mold Infection.Front Immunol, vol. 10, 2019, p. 1798. Pubmed, doi:10.3389/fimmu.2019.01798.
Rawlings SA, Heldt S, Prattes J, Eigl S, Jenks JD, Flick H, Rabensteiner J, Prüller F, Wölfler A, Neumeister P, Strohmaier H, Krause R, Hoenigl M. Using Interleukin 6 and 8 in Blood and Bronchoalveolar Lavage Fluid to Predict Survival in Hematological Malignancy Patients With Suspected Pulmonary Mold Infection. Front Immunol. 2019;10:1798.

Published In

Front Immunol

DOI

EISSN

1664-3224

Publication Date

2019

Volume

10

Start / End Page

1798

Location

Switzerland

Related Subject Headings

  • Respiratory Tract Infections
  • ROC Curve
  • Prospective Studies
  • Middle Aged
  • Mannans
  • Male
  • Interleukin-8
  • Interleukin-6
  • Humans
  • Hematologic Neoplasms