Skip to main content
release_alert
Welcome to the new Scholars 3.0! Read about new features and let us know what you think.
cancel
Journal cover image

Contributions of the NICHD neonatal research network to the diagnosis, prevention, and treatment of bronchopulmonary dysplasia.

Publication ,  Journal Article
Jensen, EA; Laughon, MM; DeMauro, SB; Cotten, CM; Do, B; Carlo, WA; Watterberg, KL
Published in: Semin Perinatol
November 2022

Despite improvements in the care and outcomes of infants born extremely preterm, bronchopulmonary dysplasia (BPD) remains a common and frustrating complication of prematurity. This review summarizes the BPD-focused research conducted by the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (NRN). To improve disease classification and outcome prediction, the NRN developed new data-driven diagnostic criteria for BPD and web-based tools that allow clinicians and investigators to reliably estimate BPD risk in preterm infants. Randomized trials of intramuscular vitamin A and prophylactic nasal continuous positive airway pressure conducted by the NRN have contributed to our current use of these therapies as evidence-based approaches to reduce BPD risk. A recent large, randomized trial of hydrocortisone administered beginning between the 2nd and 4th postnatal weeks provided strong evidence that this therapy promotes successful extubation but does not lower BPD rates. Ongoing studies within the NRN will address important, unanswered questions on the risks and benefits of intratracheal surfactant/corticosteroid combinations and treatment versus expectant management of the patent ductus arteriosus to prevent BPD.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Semin Perinatol

DOI

EISSN

1558-075X

Publication Date

November 2022

Volume

46

Issue

7

Start / End Page

151638

Location

United States

Related Subject Headings

  • Vitamin A
  • United States
  • Surface-Active Agents
  • Pulmonary Surfactants
  • Obstetrics & Reproductive Medicine
  • National Institute of Child Health and Human Development (U.S.)
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Hydrocortisone
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jensen, E. A., Laughon, M. M., DeMauro, S. B., Cotten, C. M., Do, B., Carlo, W. A., & Watterberg, K. L. (2022). Contributions of the NICHD neonatal research network to the diagnosis, prevention, and treatment of bronchopulmonary dysplasia. Semin Perinatol, 46(7), 151638. https://doi.org/10.1016/j.semperi.2022.151638
Jensen, Erik A., Matthew M. Laughon, Sara B. DeMauro, C Michael Cotten, Barbara Do, Waldemar A. Carlo, and Kristi L. Watterberg. “Contributions of the NICHD neonatal research network to the diagnosis, prevention, and treatment of bronchopulmonary dysplasia.Semin Perinatol 46, no. 7 (November 2022): 151638. https://doi.org/10.1016/j.semperi.2022.151638.
Jensen EA, Laughon MM, DeMauro SB, Cotten CM, Do B, Carlo WA, et al. Contributions of the NICHD neonatal research network to the diagnosis, prevention, and treatment of bronchopulmonary dysplasia. Semin Perinatol. 2022 Nov;46(7):151638.
Jensen, Erik A., et al. “Contributions of the NICHD neonatal research network to the diagnosis, prevention, and treatment of bronchopulmonary dysplasia.Semin Perinatol, vol. 46, no. 7, Nov. 2022, p. 151638. Pubmed, doi:10.1016/j.semperi.2022.151638.
Jensen EA, Laughon MM, DeMauro SB, Cotten CM, Do B, Carlo WA, Watterberg KL. Contributions of the NICHD neonatal research network to the diagnosis, prevention, and treatment of bronchopulmonary dysplasia. Semin Perinatol. 2022 Nov;46(7):151638.
Journal cover image

Published In

Semin Perinatol

DOI

EISSN

1558-075X

Publication Date

November 2022

Volume

46

Issue

7

Start / End Page

151638

Location

United States

Related Subject Headings

  • Vitamin A
  • United States
  • Surface-Active Agents
  • Pulmonary Surfactants
  • Obstetrics & Reproductive Medicine
  • National Institute of Child Health and Human Development (U.S.)
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Hydrocortisone