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Malignant Melanoma: Diagnostic and Management Update.

Publication ,  Journal Article
Knackstedt, T; Knackstedt, RW; Couto, R; Gastman, B
Published in: Plast Reconstr Surg
August 2018

LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Summarize the changes to the American Joint Committee on Cancer Eighth Edition Melanoma Staging System. 2. List advances in genetic, molecular, and histopathologic melanoma diagnosis and prognostication. 3. Recommend sentinel lymph node biopsy and appropriate surgical margins based on individualized patient needs. 4. Recognize the currently available treatments for in-transit metastasis and advanced melanoma. 5. Describe current and future therapies for melanoma with distant visceral or brain metastases. SUMMARY: Strides in melanoma surveillance, detection, and treatment continue to be made. The American Joint Committee on Cancer Eighth Edition Cancer Staging System has improved risk stratification of patients, introduced new staging categories, and resulted in stage migration of patients with improved outcomes. This review summarizes melanoma advances of the recent years with an emphasis on the surgical advances, including techniques and utility of sentinel node biopsy, controversies in melanoma margin selection, and the survival impact of time-to-treatment metrics. Once a disease manageable only with surgery, a therapeutic paradigm shift has given a more promising outlook to melanoma patients at any stage. Indeed, a myriad of novel, survival-improving immunotherapies have been introduced for metastatic melanoma and more recently in the high-risk adjuvant setting.

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Published In

Plast Reconstr Surg

DOI

EISSN

1529-4242

Publication Date

August 2018

Volume

142

Issue

2

Start / End Page

202e / 216e

Location

United States

Related Subject Headings

  • Surgery
  • Skin Neoplasms
  • Neoplasm Staging
  • Neoplasm Metastasis
  • Melanoma
  • Lymphatic Metastasis
  • Lymph Node Excision
  • Humans
  • Combined Modality Therapy
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Knackstedt, T., Knackstedt, R. W., Couto, R., & Gastman, B. (2018). Malignant Melanoma: Diagnostic and Management Update. Plast Reconstr Surg, 142(2), 202e-216e. https://doi.org/10.1097/PRS.0000000000004571
Knackstedt, Thomas, Rebecca W. Knackstedt, Rafael Couto, and Brian Gastman. “Malignant Melanoma: Diagnostic and Management Update.Plast Reconstr Surg 142, no. 2 (August 2018): 202e-216e. https://doi.org/10.1097/PRS.0000000000004571.
Knackstedt T, Knackstedt RW, Couto R, Gastman B. Malignant Melanoma: Diagnostic and Management Update. Plast Reconstr Surg. 2018 Aug;142(2):202e-216e.
Knackstedt, Thomas, et al. “Malignant Melanoma: Diagnostic and Management Update.Plast Reconstr Surg, vol. 142, no. 2, Aug. 2018, pp. 202e-216e. Pubmed, doi:10.1097/PRS.0000000000004571.
Knackstedt T, Knackstedt RW, Couto R, Gastman B. Malignant Melanoma: Diagnostic and Management Update. Plast Reconstr Surg. 2018 Aug;142(2):202e-216e.

Published In

Plast Reconstr Surg

DOI

EISSN

1529-4242

Publication Date

August 2018

Volume

142

Issue

2

Start / End Page

202e / 216e

Location

United States

Related Subject Headings

  • Surgery
  • Skin Neoplasms
  • Neoplasm Staging
  • Neoplasm Metastasis
  • Melanoma
  • Lymphatic Metastasis
  • Lymph Node Excision
  • Humans
  • Combined Modality Therapy
  • 1103 Clinical Sciences