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Longitudinal use of patient reported outcomes in pediatric leukemia and lymphoma reveals clinically relevant symptomatic adverse events.

Publication ,  Journal Article
Jacobs, SS; Withycombe, JS; Castellino, SM; Lin, L; Mack, JW; McFatrich, M; Baker, JN; Freyer, DR; Maurer, SH; Mowbray, C; Hinds, PS; Reeve, BB
Published in: Pediatr Blood Cancer
December 2022

BACKGROUND: Leukemia and lymphoma (LL) are the most common cancer diagnoses of childhood with high survival rates, but not without impact on the child's functioning and quality of life. This study aimed to use patient-reported data to describe the symptomatic adverse event (AE) experiences among children with LL diagnoses. METHODS: Two hundred and fifty seven children and adolescents aged 7-18 years with a first LL diagnosis completed the Pediatric Patient-Reported version of the Common Terminology Criteria for Adverse Events (Ped-PRO-CTCAE) and Patient-Reported Outcome Measurement Information System (PROMIS) Pediatric measures before starting a treatment course (T1) and after the treatment (T2). RESULTS: Fatigue was the most severe AE (68.1% at T1; 67% at T2) and caused the most interference over time. Gastrointestinal AEs were also quite common (e.g., nausea 46.3% at T1 and 48.9% at T2; abdominal pain 42.4% at T1; 46.5% at T2). In general, symptoms were present both at T1 and T2 and did not change significantly in severity or interference. The prevalence of AEs varied by LL disease group (e.g., nausea was most common in acute lymphoblastic leukemia (ALL), fatigue was most severe in ALL and Hodgkin Lymphoma (HL), acute myeloid leukemia had the fewest AEs). CONCLUSION: Despite current supportive care regimens, many children with LL continue to report fatigue, pain, insomnia, and gastrointestinal symptoms as the most frequent or severe symptoms during therapy.

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Published In

Pediatr Blood Cancer

DOI

EISSN

1545-5017

Publication Date

December 2022

Volume

69

Issue

12

Start / End Page

e29986

Location

United States

Related Subject Headings

  • Quality of Life
  • Patient Reported Outcome Measures
  • Oncology & Carcinogenesis
  • Neoplasms
  • Nausea
  • Lymphoma
  • Leukemia
  • Humans
  • Fatigue
  • Child
 

Citation

APA
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Jacobs, S. S., Withycombe, J. S., Castellino, S. M., Lin, L., Mack, J. W., McFatrich, M., … Reeve, B. B. (2022). Longitudinal use of patient reported outcomes in pediatric leukemia and lymphoma reveals clinically relevant symptomatic adverse events. Pediatr Blood Cancer, 69(12), e29986. https://doi.org/10.1002/pbc.29986
Jacobs, Shana S., Janice S. Withycombe, Sharon M. Castellino, Li Lin, Jennifer W. Mack, Molly McFatrich, Justin N. Baker, et al. “Longitudinal use of patient reported outcomes in pediatric leukemia and lymphoma reveals clinically relevant symptomatic adverse events.Pediatr Blood Cancer 69, no. 12 (December 2022): e29986. https://doi.org/10.1002/pbc.29986.
Jacobs SS, Withycombe JS, Castellino SM, Lin L, Mack JW, McFatrich M, et al. Longitudinal use of patient reported outcomes in pediatric leukemia and lymphoma reveals clinically relevant symptomatic adverse events. Pediatr Blood Cancer. 2022 Dec;69(12):e29986.
Jacobs, Shana S., et al. “Longitudinal use of patient reported outcomes in pediatric leukemia and lymphoma reveals clinically relevant symptomatic adverse events.Pediatr Blood Cancer, vol. 69, no. 12, Dec. 2022, p. e29986. Pubmed, doi:10.1002/pbc.29986.
Jacobs SS, Withycombe JS, Castellino SM, Lin L, Mack JW, McFatrich M, Baker JN, Freyer DR, Maurer SH, Mowbray C, Hinds PS, Reeve BB. Longitudinal use of patient reported outcomes in pediatric leukemia and lymphoma reveals clinically relevant symptomatic adverse events. Pediatr Blood Cancer. 2022 Dec;69(12):e29986.
Journal cover image

Published In

Pediatr Blood Cancer

DOI

EISSN

1545-5017

Publication Date

December 2022

Volume

69

Issue

12

Start / End Page

e29986

Location

United States

Related Subject Headings

  • Quality of Life
  • Patient Reported Outcome Measures
  • Oncology & Carcinogenesis
  • Neoplasms
  • Nausea
  • Lymphoma
  • Leukemia
  • Humans
  • Fatigue
  • Child