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Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes.

Publication ,  Journal Article
Meyer, LC; Paisley, CE; Mohamed, E; Bigbee, JW; Kordula, T; Richard, H; Lutfy, K; Sato-Bigbee, C
Published in: Glia
December 2017

Our previous results showed that oligodendrocyte development is regulated by both nociceptin and its G-protein coupled receptor, the nociceptin/orphanin FQ receptor (NOR). The present in vitro and in vivo findings show that nociceptin plays a crucial conserved role regulating the levels of the glutamate/aspartate transporter GLAST/EAAT1 in both human and rodent brain astrocytes. This nociceptin-mediated response takes place during a critical developmental window that coincides with the early stages of astrocyte maturation. GLAST/EAAT1 upregulation by nociceptin is mediated by NOR and the downstream participation of a complex signaling cascade that involves the interaction of several kinase systems, including PI-3K/AKT, mTOR, and JAK. Because GLAST is the main glutamate transporter during brain maturation, these novel findings suggest that nociceptin plays a crucial role in regulating the function of early astrocytes and their capacity to support glutamate homeostasis in the developing brain.

Duke Scholars

Published In

Glia

DOI

EISSN

1098-1136

ISSN

0894-1491

Publication Date

December 2017

Volume

65

Issue

12

Start / End Page

2003 / 2023

Related Subject Headings

  • Signal Transduction
  • Retinal Dehydrogenase
  • Receptors, Opioid
  • Rats, Sprague-Dawley
  • Rats
  • Opioid Peptides
  • Nociceptin Receptor
  • Nociceptin
  • Neurons
  • Neurology & Neurosurgery
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Meyer, L. C., Paisley, C. E., Mohamed, E., Bigbee, J. W., Kordula, T., Richard, H., … Sato-Bigbee, C. (2017). Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes. Glia, 65(12), 2003–2023. https://doi.org/10.1002/glia.23210
Meyer, Logan C., Caitlin E. Paisley, Esraa Mohamed, John W. Bigbee, Tomasz Kordula, Hope Richard, Kabirullah Lutfy, and Carmen Sato-Bigbee. “Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes.Glia 65, no. 12 (December 2017): 2003–23. https://doi.org/10.1002/glia.23210.
Meyer LC, Paisley CE, Mohamed E, Bigbee JW, Kordula T, Richard H, et al. Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes. Glia. 2017 Dec;65(12):2003–23.
Meyer, Logan C., et al. “Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes.Glia, vol. 65, no. 12, Dec. 2017, pp. 2003–23. Epmc, doi:10.1002/glia.23210.
Meyer LC, Paisley CE, Mohamed E, Bigbee JW, Kordula T, Richard H, Lutfy K, Sato-Bigbee C. Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes. Glia. 2017 Dec;65(12):2003–2023.
Journal cover image

Published In

Glia

DOI

EISSN

1098-1136

ISSN

0894-1491

Publication Date

December 2017

Volume

65

Issue

12

Start / End Page

2003 / 2023

Related Subject Headings

  • Signal Transduction
  • Retinal Dehydrogenase
  • Receptors, Opioid
  • Rats, Sprague-Dawley
  • Rats
  • Opioid Peptides
  • Nociceptin Receptor
  • Nociceptin
  • Neurons
  • Neurology & Neurosurgery