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Urine pH and phencyclidine excretion.

Publication ,  Journal Article
Perez-Reyes, M; Di Guiseppi, S; Brine, DR; Smith, H; Cook, CE
Published in: Clin Pharmacol Ther
November 1982
Published version (DOI) Link to item

Subeffective doses (0.5 mg) of 3H-phencyclidine (PCP) were given intravenously to three healthy men under two regimens designed to alkalinize or acidify their urine (oral sodium bicarbonate or ammonium chloride). The concentrations of PCP and its metabolites in saliva, plasma, and urine for 7 hr after injection were determined by high-performance liquid radiochromatography. A sample of perspiration from one subject was analyzed. The effects of physical exercise on the plasma concentration and urinary excretion of PCP were also studied. Multiple linear regression analysis showed the logarithm of renal clearance the renal clearance of PCP. PCP and its metabolites are also excreted in perspiration. Our results support clinical reports of the importance of vigorous acidification of urine and diuresis in treatment of PCP intoxication.

Duke Scholars

Chad E. Cook
Author Chad E. Cook Orthopaedic Surgery, Physical Therapy

Published In

Clin Pharmacol Ther

DOI

10.1038/clpt.1982.214

ISSN

0009-9236

Publication Date

November 1982

Volume

32

Issue

5

Start / End Page

635 / 641

Location

United States

Related Subject Headings

  • Sweat
  • Regression Analysis
  • Physical Exertion
  • Phencyclidine
  • Pharmacology & Pharmacy
  • Male
  • Hydrogen-Ion Concentration
  • Humans
  • Chromatography, High Pressure Liquid
  • Adult
 

Citation

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Perez-Reyes, M., Di Guiseppi, S., Brine, D. R., Smith, H., & Cook, C. E. (1982). Urine pH and phencyclidine excretion. Clin Pharmacol Ther, 32(5), 635–641. https://doi.org/10.1038/clpt.1982.214
Perez-Reyes, M., S. Di Guiseppi, D. R. Brine, H. Smith, and C. E. Cook. “Urine pH and phencyclidine excretion.” Clin Pharmacol Ther 32, no. 5 (November 1982): 635–41. https://doi.org/10.1038/clpt.1982.214.
Perez-Reyes M, Di Guiseppi S, Brine DR, Smith H, Cook CE. Urine pH and phencyclidine excretion. Clin Pharmacol Ther. 1982 Nov;32(5):635–41.
Perez-Reyes, M., et al. “Urine pH and phencyclidine excretion.” Clin Pharmacol Ther, vol. 32, no. 5, Nov. 1982, pp. 635–41. Pubmed, doi:10.1038/clpt.1982.214.
Perez-Reyes M, Di Guiseppi S, Brine DR, Smith H, Cook CE. Urine pH and phencyclidine excretion. Clin Pharmacol Ther. 1982 Nov;32(5):635–641.
Journal cover image

Published In

Clin Pharmacol Ther

DOI

10.1038/clpt.1982.214

ISSN

0009-9236

Publication Date

November 1982

Volume

32

Issue

5

Start / End Page

635 / 641

Location

United States

Related Subject Headings

  • Sweat
  • Regression Analysis
  • Physical Exertion
  • Phencyclidine
  • Pharmacology & Pharmacy
  • Male
  • Hydrogen-Ion Concentration
  • Humans
  • Chromatography, High Pressure Liquid
  • Adult