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Interaction between marihuana and ethanol: effects on psychomotor performance.

Publication ,  Journal Article
Perez-Reyes, M; Hicks, RE; Bumberry, J; Jeffcoat, AR; Cook, CE
Published in: Alcohol Clin Exp Res
April 1988

This is a report of the results of a placebo-controlled study in which the effects of the interaction between ethanol and marihuana on drug plasma concentrations, subjective ratings of intoxication, heart rate acceleration, and psychomotor performance were investigated. Six healthy, male, paid volunteers, moderate users of ethanol and marihuana, participated in the study. Ethanol (0.42 g/kg, 0.85 g/kg, or placebo) was administered over a 30-min interval. Fifteen minutes later the subjects smoked, in their customary manner, NIDA cigarettes containing 2.4% or 0.0004% (placebo) delta-9-tetrahydrocannabinol (THC). Each subject was tested in a single-blind, latin-square crossover design with the following six conditions: placebo ethanol/placebo marihuana; low dose ethanol/placebo marihuana; high dose ethanol/placebo marihuana; placebo ethanol/marihuana; low dose ethanol/marihuana; and high dose ethanol/marihuana. The variables measured in the study were: (a) subjective rating of ethanol and/or marihuana intoxication; (b) heart rate; (c) accuracy and latency of response in the Simulator Evaluation of Drug Impairment (SEDI) task; (d) blood ethanol concentration by gas chromatography; and (e) plasma concentration of THC by radioimmunoassay. The results indicate that the decrements due to ethanol in performance of skills necessary to drive an automobile were significantly enhanced by marihuana in an additive and perhaps synergistic manner. The administration of ethanol prior to marihuana smoking did not produce significant effects on the subjective rating of "high," heart rate acceleration, or THC plasma concentration.

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Published In

Alcohol Clin Exp Res

DOI

ISSN

0145-6008

Publication Date

April 1988

Volume

12

Issue

2

Start / End Page

268 / 276

Location

England

Related Subject Headings

  • Substance Abuse
  • Reaction Time
  • Random Allocation
  • Psychomotor Performance
  • Marijuana Smoking
  • Male
  • Humans
  • Heart Rate
  • Ethanol
  • Drug Interactions
 

Citation

APA
Chicago
ICMJE
MLA
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Perez-Reyes, M., Hicks, R. E., Bumberry, J., Jeffcoat, A. R., & Cook, C. E. (1988). Interaction between marihuana and ethanol: effects on psychomotor performance. Alcohol Clin Exp Res, 12(2), 268–276. https://doi.org/10.1111/j.1530-0277.1988.tb00193.x
Perez-Reyes, M., R. E. Hicks, J. Bumberry, A. R. Jeffcoat, and C. E. Cook. “Interaction between marihuana and ethanol: effects on psychomotor performance.Alcohol Clin Exp Res 12, no. 2 (April 1988): 268–76. https://doi.org/10.1111/j.1530-0277.1988.tb00193.x.
Perez-Reyes M, Hicks RE, Bumberry J, Jeffcoat AR, Cook CE. Interaction between marihuana and ethanol: effects on psychomotor performance. Alcohol Clin Exp Res. 1988 Apr;12(2):268–76.
Perez-Reyes, M., et al. “Interaction between marihuana and ethanol: effects on psychomotor performance.Alcohol Clin Exp Res, vol. 12, no. 2, Apr. 1988, pp. 268–76. Pubmed, doi:10.1111/j.1530-0277.1988.tb00193.x.
Perez-Reyes M, Hicks RE, Bumberry J, Jeffcoat AR, Cook CE. Interaction between marihuana and ethanol: effects on psychomotor performance. Alcohol Clin Exp Res. 1988 Apr;12(2):268–276.
Journal cover image

Published In

Alcohol Clin Exp Res

DOI

ISSN

0145-6008

Publication Date

April 1988

Volume

12

Issue

2

Start / End Page

268 / 276

Location

England

Related Subject Headings

  • Substance Abuse
  • Reaction Time
  • Random Allocation
  • Psychomotor Performance
  • Marijuana Smoking
  • Male
  • Humans
  • Heart Rate
  • Ethanol
  • Drug Interactions