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A complex pattern of disposition of phenytoin in severe intoxication.

Publication ,  Journal Article
Pruitt, AW; Zwiren, GT; Patterson, JH; Dayton, PG; Cook, CE; Wall, ME
Published in: Clin Pharmacol Ther
July 1975

A 5-year-old child developed phenytoin (diphenylhydantoin, DPH) toxicity after receiving 500 mg of the drug daily for 3 weeks. Plasma, urine, and duodenal fluid were collected for assay of DPH and its metabolites. The peak plasma concentration of DPH was 108 mug/ml, and the decline in plasma level did not fit first-order kinetics. The para-hydroxy, meta-hydroxy, and dihydrodiol metabolites of DPH were measured in urine; duodenal aspirate contained both DPH and the para-hydroxy metabolite. Plasma pH may affect distribution of DPH since in vitro binding of DPH to human albumin increased as pH increased.

Duke Scholars

Published In

Clin Pharmacol Ther

DOI

ISSN

0009-9236

Publication Date

July 1975

Volume

18

Issue

1

Start / End Page

112 / 120

Location

United States

Related Subject Headings

  • Time Factors
  • Solubility
  • Serum Albumin
  • Seizures
  • Protein Binding
  • Phenytoin
  • Pharmacology & Pharmacy
  • Medication Errors
  • Male
  • Kinetics
 

Citation

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Pruitt, A. W., Zwiren, G. T., Patterson, J. H., Dayton, P. G., Cook, C. E., & Wall, M. E. (1975). A complex pattern of disposition of phenytoin in severe intoxication. Clin Pharmacol Ther, 18(1), 112–120. https://doi.org/10.1002/cpt1975181112
Pruitt, A. W., G. T. Zwiren, J. H. Patterson, P. G. Dayton, C. E. Cook, and M. E. Wall. “A complex pattern of disposition of phenytoin in severe intoxication.Clin Pharmacol Ther 18, no. 1 (July 1975): 112–20. https://doi.org/10.1002/cpt1975181112.
Pruitt AW, Zwiren GT, Patterson JH, Dayton PG, Cook CE, Wall ME. A complex pattern of disposition of phenytoin in severe intoxication. Clin Pharmacol Ther. 1975 Jul;18(1):112–20.
Pruitt, A. W., et al. “A complex pattern of disposition of phenytoin in severe intoxication.Clin Pharmacol Ther, vol. 18, no. 1, July 1975, pp. 112–20. Pubmed, doi:10.1002/cpt1975181112.
Pruitt AW, Zwiren GT, Patterson JH, Dayton PG, Cook CE, Wall ME. A complex pattern of disposition of phenytoin in severe intoxication. Clin Pharmacol Ther. 1975 Jul;18(1):112–120.
Journal cover image

Published In

Clin Pharmacol Ther

DOI

ISSN

0009-9236

Publication Date

July 1975

Volume

18

Issue

1

Start / End Page

112 / 120

Location

United States

Related Subject Headings

  • Time Factors
  • Solubility
  • Serum Albumin
  • Seizures
  • Protein Binding
  • Phenytoin
  • Pharmacology & Pharmacy
  • Medication Errors
  • Male
  • Kinetics