The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer?
Publication
, Journal Article
Hu, ZI; McArthur, HL; Ho, AY
Published in: Current Breast Cancer Reports
March 1, 2017
The abscopal effect refers to the ability of localized radiation to trigger systemic antitumor effects. Over the past 50 years, reports on the abscopal effect arising from conventional radiation have been relatively rare. However, with the continued development and use of immunotherapy strategies incorporating radiotherapy with targeted immunomodulators and immune checkpoint blockade, the abscopal effect is becoming increasingly relevant in less immunogenic tumors such as breast cancer. Here, we review the mechanism of the abscopal effect, the current preclinical and clinical data, and the application of the abscopal effect in designing clinical trials of immunotherapy combined with radiotherapy in breast cancer.
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Published In
Current Breast Cancer Reports
DOI
EISSN
1943-4596
ISSN
1943-4588
Publication Date
March 1, 2017
Volume
9
Issue
1
Start / End Page
45 / 51
Related Subject Headings
- 3211 Oncology and carcinogenesis
- 1112 Oncology and Carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Hu, Z. I., McArthur, H. L., & Ho, A. Y. (2017). The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer? Current Breast Cancer Reports, 9(1), 45–51. https://doi.org/10.1007/s12609-017-0234-y
Hu, Z. I., H. L. McArthur, and A. Y. Ho. “The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer?” Current Breast Cancer Reports 9, no. 1 (March 1, 2017): 45–51. https://doi.org/10.1007/s12609-017-0234-y.
Hu ZI, McArthur HL, Ho AY. The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer? Current Breast Cancer Reports. 2017 Mar 1;9(1):45–51.
Hu, Z. I., et al. “The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer?” Current Breast Cancer Reports, vol. 9, no. 1, Mar. 2017, pp. 45–51. Scopus, doi:10.1007/s12609-017-0234-y.
Hu ZI, McArthur HL, Ho AY. The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer? Current Breast Cancer Reports. 2017 Mar 1;9(1):45–51.
Published In
Current Breast Cancer Reports
DOI
EISSN
1943-4596
ISSN
1943-4588
Publication Date
March 1, 2017
Volume
9
Issue
1
Start / End Page
45 / 51
Related Subject Headings
- 3211 Oncology and carcinogenesis
- 1112 Oncology and Carcinogenesis