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Coupled oscillators coordinate collective germline growth.

Publication ,  Journal Article
Doherty, CA; Diegmiller, R; Kapasiawala, M; Gavis, ER; Shvartsman, SY
Published in: Developmental cell
March 2021

Developing oocytes need large supplies of macromolecules and organelles. A conserved strategy for accumulating these products is to pool resources of oocyte-associated germline nurse cells. In Drosophila, these cells grow more than 100-fold to boost their biosynthetic capacity. No previously known mechanism explains how nurse cells coordinate growth collectively. Here, we report a cell cycle-regulating mechanism that depends on bidirectional communication between the oocyte and nurse cells, revealing the oocyte as a critical regulator of germline cyst growth. Transcripts encoding the cyclin-dependent kinase inhibitor, Dacapo, are synthesized by the nurse cells and actively localized to the oocyte. Retrograde movement of the oocyte-synthesized Dacapo protein to the nurse cells generates a network of coupled oscillators that controls the cell cycle of the nurse cells to regulate cyst growth. We propose that bidirectional nurse cell-oocyte communication establishes a growth-sensing feedback mechanism that regulates the quantity of maternal resources loaded into the oocyte.

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Published In

Developmental cell

DOI

EISSN

1878-1551

ISSN

1534-5807

Publication Date

March 2021

Volume

56

Issue

6

Start / End Page

860 / 870.e8

Related Subject Headings

  • Oogenesis
  • Oocytes
  • Nuclear Proteins
  • Germ Cells
  • Female
  • Drosophila melanogaster
  • Drosophila Proteins
  • Developmental Biology
  • Cell Differentiation
  • Cell Communication
 

Citation

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ICMJE
MLA
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Doherty, C. A., Diegmiller, R., Kapasiawala, M., Gavis, E. R., & Shvartsman, S. Y. (2021). Coupled oscillators coordinate collective germline growth. Developmental Cell, 56(6), 860-870.e8. https://doi.org/10.1016/j.devcel.2021.02.015
Doherty, Caroline A., Rocky Diegmiller, Manisha Kapasiawala, Elizabeth R. Gavis, and Stanislav Y. Shvartsman. “Coupled oscillators coordinate collective germline growth.Developmental Cell 56, no. 6 (March 2021): 860-870.e8. https://doi.org/10.1016/j.devcel.2021.02.015.
Doherty CA, Diegmiller R, Kapasiawala M, Gavis ER, Shvartsman SY. Coupled oscillators coordinate collective germline growth. Developmental cell. 2021 Mar;56(6):860-870.e8.
Doherty, Caroline A., et al. “Coupled oscillators coordinate collective germline growth.Developmental Cell, vol. 56, no. 6, Mar. 2021, pp. 860-870.e8. Epmc, doi:10.1016/j.devcel.2021.02.015.
Doherty CA, Diegmiller R, Kapasiawala M, Gavis ER, Shvartsman SY. Coupled oscillators coordinate collective germline growth. Developmental cell. 2021 Mar;56(6):860-870.e8.
Journal cover image

Published In

Developmental cell

DOI

EISSN

1878-1551

ISSN

1534-5807

Publication Date

March 2021

Volume

56

Issue

6

Start / End Page

860 / 870.e8

Related Subject Headings

  • Oogenesis
  • Oocytes
  • Nuclear Proteins
  • Germ Cells
  • Female
  • Drosophila melanogaster
  • Drosophila Proteins
  • Developmental Biology
  • Cell Differentiation
  • Cell Communication