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Sex-Based Differences in Periprocedural Complications Following Lower Extremity Peripheral Vascular Intervention.

Publication ,  Journal Article
Altin, SE; Gitto, M; Secemsky, EA; Rao, SV; Hess, CN
Published in: Circ Cardiovasc Interv
August 2022

BACKGROUND: Women with coronary artery disease are shown to have worse outcomes after percutaneous coronary intervention compared with men; however, less is known about sex-based outcomes following lower extremity peripheral vascular intervention (PVI) for symptomatic peripheral artery disease. The study aims to assess whether female sex is independently associated with periprocedural complications in patients undergoing PVI. METHODS: Analysis includes patients undergoing lower extremity PVI from September 2016 to March 2020 from the Vascular Quality Initiative registry. Multivariate logistic regression was used to assess the independent association of female sex with post-PVI complications. RESULTS: Of the 119 620 patients included, 47 316 (39.6%) were women. Analysis reflected that women were at higher risk of developing access site complications, including any hematoma (odds ratio [OR], 1.45 [1.35-1.57]), hematoma requiring transfusion (OR, 2.24 [1.82-2.76]; P<0.001), hematoma requiring surgery (OR, 1.49 [1.19-1.86]; P<0.001), pseudoaneurysm (OR, 1.69 [1.39-2.05]; P<0.001), and access site occlusion (OR, 1.89 [1.15-3.08]; P<0.001). Women also faced higher risks of target lesion dissection (OR, 1.36 [1.26-1.46]; P<0.001), above-knee amputation (OR, 1.37 [1.18-1.58]; P<0.001), and in-hospital mortality (OR, 1.21 [1.07-1.38]; P=0.003). CONCLUSIONS: In a contemporary cohort, women undergoing lower extremity PVI for symptomatic peripheral artery disease were at higher risk than men of developing periprocedural complications, including moderate or severe access site bleeding, above-knee amputation, and in-hospital mortality. This increased risk persisted despite adjustment for differences in baseline patient or procedural characteristics and warrants further investigation.

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Published In

Circ Cardiovasc Interv

DOI

EISSN

1941-7632

Publication Date

August 2022

Volume

15

Issue

8

Start / End Page

e011768

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Risk Factors
  • Retrospective Studies
  • Peripheral Arterial Disease
  • Odds Ratio
  • Male
  • Lower Extremity
  • Humans
  • Hematoma
  • Female
 

Citation

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Altin, S. E., Gitto, M., Secemsky, E. A., Rao, S. V., & Hess, C. N. (2022). Sex-Based Differences in Periprocedural Complications Following Lower Extremity Peripheral Vascular Intervention. Circ Cardiovasc Interv, 15(8), e011768. https://doi.org/10.1161/CIRCINTERVENTIONS.121.011768
Altin, S Elissa, Mauro Gitto, Eric A. Secemsky, Sunil V. Rao, and Connie N. Hess. “Sex-Based Differences in Periprocedural Complications Following Lower Extremity Peripheral Vascular Intervention.Circ Cardiovasc Interv 15, no. 8 (August 2022): e011768. https://doi.org/10.1161/CIRCINTERVENTIONS.121.011768.
Altin SE, Gitto M, Secemsky EA, Rao SV, Hess CN. Sex-Based Differences in Periprocedural Complications Following Lower Extremity Peripheral Vascular Intervention. Circ Cardiovasc Interv. 2022 Aug;15(8):e011768.
Altin, S. Elissa, et al. “Sex-Based Differences in Periprocedural Complications Following Lower Extremity Peripheral Vascular Intervention.Circ Cardiovasc Interv, vol. 15, no. 8, Aug. 2022, p. e011768. Pubmed, doi:10.1161/CIRCINTERVENTIONS.121.011768.
Altin SE, Gitto M, Secemsky EA, Rao SV, Hess CN. Sex-Based Differences in Periprocedural Complications Following Lower Extremity Peripheral Vascular Intervention. Circ Cardiovasc Interv. 2022 Aug;15(8):e011768.

Published In

Circ Cardiovasc Interv

DOI

EISSN

1941-7632

Publication Date

August 2022

Volume

15

Issue

8

Start / End Page

e011768

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Risk Factors
  • Retrospective Studies
  • Peripheral Arterial Disease
  • Odds Ratio
  • Male
  • Lower Extremity
  • Humans
  • Hematoma
  • Female