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Design and Characterization of Hyperpolarized 15N-BBCP as a H2O2-Sensing Probe.

Publication ,  Journal Article
Park, H; Chen, J; Dimitrov, IE; Park, JM; Wang, Q
Published in: ACS sensors
October 2022

Hydrogen peroxide (H2O2) is a type of reactive oxygen species that regulates essential biological processes. Despite the central role of H2O2 in pathophysiological states, available molecular probes for assessing H2O2in vivo are still limited. This work develops hyperpolarized 15N-boronobenzyl-4-cyanopyridinium (15N-BBCP) as a rationally designed molecular probe for detecting H2O2. The 15N-BBCP demonstrated favorable physicochemical and biochemical properties for H2O2 detection and dynamic nuclear polarization, allowing noninvasive detection of H2O2. In particular, 15N-BBCP and the products possessed long spin-lattice relaxation times and spectrally resolvable 15N chemical shift differences. The performance of hyperpolarized 15N-BBCP was demonstrated both in vitro and in vivo with time-resolved 15N-MRS. This study highlights a promising approach to designing a reaction-based 15N-labeled molecular imaging agent for detecting oxidative stress in vivo.

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Published In

ACS sensors

DOI

EISSN

2379-3694

ISSN

2379-3694

Publication Date

October 2022

Volume

7

Issue

10

Start / End Page

2928 / 2933

Related Subject Headings

  • Reactive Oxygen Species
  • Oxidative Stress
  • Molecular Probes
  • Molecular Imaging
  • Hydrogen Peroxide
  • 4009 Electronics, sensors and digital hardware
  • 3401 Analytical chemistry
  • 1007 Nanotechnology
  • 0903 Biomedical Engineering
  • 0301 Analytical Chemistry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Park, H., Chen, J., Dimitrov, I. E., Park, J. M., & Wang, Q. (2022). Design and Characterization of Hyperpolarized 15N-BBCP as a H2O2-Sensing Probe. ACS Sensors, 7(10), 2928–2933. https://doi.org/10.1021/acssensors.2c01720
Park, Hyejin, Jun Chen, Ivan E. Dimitrov, Jae Mo Park, and Qiu Wang. “Design and Characterization of Hyperpolarized 15N-BBCP as a H2O2-Sensing Probe.ACS Sensors 7, no. 10 (October 2022): 2928–33. https://doi.org/10.1021/acssensors.2c01720.
Park H, Chen J, Dimitrov IE, Park JM, Wang Q. Design and Characterization of Hyperpolarized 15N-BBCP as a H2O2-Sensing Probe. ACS sensors. 2022 Oct;7(10):2928–33.
Park, Hyejin, et al. “Design and Characterization of Hyperpolarized 15N-BBCP as a H2O2-Sensing Probe.ACS Sensors, vol. 7, no. 10, Oct. 2022, pp. 2928–33. Epmc, doi:10.1021/acssensors.2c01720.
Park H, Chen J, Dimitrov IE, Park JM, Wang Q. Design and Characterization of Hyperpolarized 15N-BBCP as a H2O2-Sensing Probe. ACS sensors. 2022 Oct;7(10):2928–2933.
Journal cover image

Published In

ACS sensors

DOI

EISSN

2379-3694

ISSN

2379-3694

Publication Date

October 2022

Volume

7

Issue

10

Start / End Page

2928 / 2933

Related Subject Headings

  • Reactive Oxygen Species
  • Oxidative Stress
  • Molecular Probes
  • Molecular Imaging
  • Hydrogen Peroxide
  • 4009 Electronics, sensors and digital hardware
  • 3401 Analytical chemistry
  • 1007 Nanotechnology
  • 0903 Biomedical Engineering
  • 0301 Analytical Chemistry