A path to translation: How 3D patient tumor avatars enable next generation precision oncology.
Publication
, Journal Article
Bose, S; Barroso, M; Chheda, MG; Clevers, H; Elez, E; Kaochar, S; Kopetz, SE; Li, X-N; Meric-Bernstam, F; Meyer, CA; Mou, H; Naegle, KM ...
Published in: Cancer Cell
December 12, 2022
3D patient tumor avatars (3D-PTAs) hold promise for next-generation precision medicine. Here, we describe the benefits and challenges of 3D-PTA technologies and necessary future steps to realize their potential for clinical decision making. 3D-PTAs require standardization criteria and prospective trials to establish clinical benefits. Innovative trial designs that combine omics and 3D-PTA readouts may lead to more accurate clinical predictors, and an integrated platform that combines diagnostic and therapeutic development will accelerate new treatments for patients with refractory disease.
Duke Scholars
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Published In
Cancer Cell
DOI
EISSN
1878-3686
Publication Date
December 12, 2022
Volume
40
Issue
12
Start / End Page
1448 / 1453
Location
United States
Related Subject Headings
- Prospective Studies
- Precision Medicine
- Oncology & Carcinogenesis
- Neoplasms
- Medical Oncology
- Humans
- 1112 Oncology and Carcinogenesis
- 1109 Neurosciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Bose, S., Barroso, M., Chheda, M. G., Clevers, H., Elez, E., Kaochar, S., … Shen, X. (2022). A path to translation: How 3D patient tumor avatars enable next generation precision oncology. Cancer Cell, 40(12), 1448–1453. https://doi.org/10.1016/j.ccell.2022.09.017
Bose, Shree, Margarida Barroso, Milan G. Chheda, Hans Clevers, Elena Elez, Salma Kaochar, Scott E. Kopetz, et al. “A path to translation: How 3D patient tumor avatars enable next generation precision oncology.” Cancer Cell 40, no. 12 (December 12, 2022): 1448–53. https://doi.org/10.1016/j.ccell.2022.09.017.
Bose S, Barroso M, Chheda MG, Clevers H, Elez E, Kaochar S, et al. A path to translation: How 3D patient tumor avatars enable next generation precision oncology. Cancer Cell. 2022 Dec 12;40(12):1448–53.
Bose, Shree, et al. “A path to translation: How 3D patient tumor avatars enable next generation precision oncology.” Cancer Cell, vol. 40, no. 12, Dec. 2022, pp. 1448–53. Pubmed, doi:10.1016/j.ccell.2022.09.017.
Bose S, Barroso M, Chheda MG, Clevers H, Elez E, Kaochar S, Kopetz SE, Li X-N, Meric-Bernstam F, Meyer CA, Mou H, Naegle KM, Pera MF, Perova Z, Politi KA, Raphael BJ, Robson P, Sears RC, Tabernero J, Tuveson DA, Welm AL, Welm BE, Willey CD, Salnikow K, Chuang JH, Shen X. A path to translation: How 3D patient tumor avatars enable next generation precision oncology. Cancer Cell. 2022 Dec 12;40(12):1448–1453.
Published In
Cancer Cell
DOI
EISSN
1878-3686
Publication Date
December 12, 2022
Volume
40
Issue
12
Start / End Page
1448 / 1453
Location
United States
Related Subject Headings
- Prospective Studies
- Precision Medicine
- Oncology & Carcinogenesis
- Neoplasms
- Medical Oncology
- Humans
- 1112 Oncology and Carcinogenesis
- 1109 Neurosciences