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Interrogating the Roles of Mutation-Selection Balance, Heterozygote Advantage, and Linked Selection in Maintaining Recessive Lethal Variation in Natural Populations.

Publication ,  Journal Article
Marion, SB; Noor, MAF
Published in: Annual review of animal biosciences
February 2023

For nearly a century, evolutionary biologists have observed chromosomes that cause lethality when made homozygous persisting at surprisingly high frequencies (>25%) in natural populations of many species. The evolutionary forces responsible for the maintenance of such detrimental mutations have been heavily debated-are some lethal mutations under balancing selection? We suggest that mutation-selection balance alone cannot explain lethal variation in nature and the possibility that other forces play a role. We review the potential that linked selection in particular may drive maintenance of lethal alleles through associative overdominance or linkage to beneficial mutations or by reducing effective population size. Over the past five decades, investigation into this mystery has tapered. During this time, key scientific advances have provided the ability to collect more accurate data and analyze them in new ways, making the underlying genetic bases and evolutionary forces of lethal alleles timely for study once more.

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Published In

Annual review of animal biosciences

DOI

EISSN

2165-8110

ISSN

2165-8102

Publication Date

February 2023

Volume

11

Start / End Page

77 / 91

Related Subject Headings

  • Selection, Genetic
  • Mutation
  • Heterozygote
  • Genetic Variation
  • Chromosomes
  • Biological Evolution
  • Animals
  • 3105 Genetics
  • 3009 Veterinary sciences
  • 3003 Animal production
 

Citation

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Marion, S. B., & Noor, M. A. F. (2023). Interrogating the Roles of Mutation-Selection Balance, Heterozygote Advantage, and Linked Selection in Maintaining Recessive Lethal Variation in Natural Populations. Annual Review of Animal Biosciences, 11, 77–91. https://doi.org/10.1146/annurev-animal-050422-092520
Marion, Sarah B., and Mohamed A. F. Noor. “Interrogating the Roles of Mutation-Selection Balance, Heterozygote Advantage, and Linked Selection in Maintaining Recessive Lethal Variation in Natural Populations.Annual Review of Animal Biosciences 11 (February 2023): 77–91. https://doi.org/10.1146/annurev-animal-050422-092520.
Marion, Sarah B., and Mohamed A. F. Noor. “Interrogating the Roles of Mutation-Selection Balance, Heterozygote Advantage, and Linked Selection in Maintaining Recessive Lethal Variation in Natural Populations.Annual Review of Animal Biosciences, vol. 11, Feb. 2023, pp. 77–91. Epmc, doi:10.1146/annurev-animal-050422-092520.

Published In

Annual review of animal biosciences

DOI

EISSN

2165-8110

ISSN

2165-8102

Publication Date

February 2023

Volume

11

Start / End Page

77 / 91

Related Subject Headings

  • Selection, Genetic
  • Mutation
  • Heterozygote
  • Genetic Variation
  • Chromosomes
  • Biological Evolution
  • Animals
  • 3105 Genetics
  • 3009 Veterinary sciences
  • 3003 Animal production