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Health-Related Quality of Life Outcomes in Older Hematopoietic Cell Transplantation Survivors.

Publication ,  Journal Article
Hong, S; Zhao, J; Wang, S; Wang, H; Lee, J-H; Farhadfar, N; McGuirk, JP; Savani, BN; Shahrukh, HK; Stiff, P; Khera, N; Hahn, T; Loren, AW ...
Published in: Transplant Cell Ther
March 2023

The use of hematopoietic cell transplantation (HCT) has been increasing in older patients. However, the levels if distress, psychosocial functioning, and health-related quality of life (HRQOL) among older HCT survivors remains largely unknown. In this secondary analysis using data from 2 randomized controlled trials, we analyzed baseline Cancer and Treatment Distress (CTXD) and Confidence In Survivorship Information (CSI) surveys of HCT survivors who were age ≥60 years at the time of transplantation and alive and disease-free ≥1 year post-autologous or -allogeneic HCT. We analyzed associations of these parameters with the Physical Component Summary (PCS) and Mental Component Summary (MCS) scores of the 12-Item Short Form Survey (SF-12) and a healthcare adherence (HCA) scale, after adjusting for transplantation and patient demographic factors. A total of 567 patients were included. The median patient age at HCT was 65 years, and 68% of the patients underwent autologous HCT. The median CTXD score was .7 (mild), and the greatest distress was reported in the "health burden" subscale. The median CSI score was 1.4 (moderate-high), with the lowest confidence reported in the "late effects" subscale. We found negative Spearman correlations between CTXD score and SF-12 PCS (P = -.59) and MCS (P = -.54) and positive Spearman correlations between CSI score and SF-12 PCS (P = .23) and MCS (P = .30). The median HCA scale score was high at .8. Male sex, autologous HCT, increased distress level, and worse CSI score were associated with lower use of preventive care. Older survivors experienced a low level of distress and moderate-high level of CSI at ≥1 year post-HCT. As lower distress and higher CSI were associated with improved HRQOL and optimized preventive HCA, CTXD/CSI measures can be used to individualize the care of older adult HCT survivors.

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Published In

Transplant Cell Ther

DOI

EISSN

2666-6367

Publication Date

March 2023

Volume

29

Issue

3

Start / End Page

202.e1 / 202.e8

Location

United States

Related Subject Headings

  • Survivors
  • Surveys and Questionnaires
  • Quality of Life
  • Neoplasms
  • Middle Aged
  • Male
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Aged
 

Citation

APA
Chicago
ICMJE
MLA
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Hong, S., Zhao, J., Wang, S., Wang, H., Lee, J.-H., Farhadfar, N., … Al-Mansour, Z. (2023). Health-Related Quality of Life Outcomes in Older Hematopoietic Cell Transplantation Survivors. Transplant Cell Ther, 29(3), 202.e1-202.e8. https://doi.org/10.1016/j.jtct.2022.11.016
Hong, Sanghee, Jing Zhao, Shu Wang, Han Wang, Ji-Hyun Lee, Nosha Farhadfar, Joseph P. McGuirk, et al. “Health-Related Quality of Life Outcomes in Older Hematopoietic Cell Transplantation Survivors.Transplant Cell Ther 29, no. 3 (March 2023): 202.e1-202.e8. https://doi.org/10.1016/j.jtct.2022.11.016.
Hong S, Zhao J, Wang S, Wang H, Lee J-H, Farhadfar N, et al. Health-Related Quality of Life Outcomes in Older Hematopoietic Cell Transplantation Survivors. Transplant Cell Ther. 2023 Mar;29(3):202.e1-202.e8.
Hong, Sanghee, et al. “Health-Related Quality of Life Outcomes in Older Hematopoietic Cell Transplantation Survivors.Transplant Cell Ther, vol. 29, no. 3, Mar. 2023, pp. 202.e1-202.e8. Pubmed, doi:10.1016/j.jtct.2022.11.016.
Hong S, Zhao J, Wang S, Wang H, Lee J-H, Farhadfar N, McGuirk JP, Savani BN, Shahrukh HK, Stiff P, Khera N, Hahn T, Loren AW, Jaglowski SM, Wood WA, Saber W, Cerny J, Holtan SG, Reynolds JM, Deol A, Jim H, Uberti J, Whalen V, Yi JC, Preussler J, Baker KS, Shaw BE, Devine S, Syrjala K, Majhail NS, Wingard JR, Al-Mansour Z. Health-Related Quality of Life Outcomes in Older Hematopoietic Cell Transplantation Survivors. Transplant Cell Ther. 2023 Mar;29(3):202.e1-202.e8.

Published In

Transplant Cell Ther

DOI

EISSN

2666-6367

Publication Date

March 2023

Volume

29

Issue

3

Start / End Page

202.e1 / 202.e8

Location

United States

Related Subject Headings

  • Survivors
  • Surveys and Questionnaires
  • Quality of Life
  • Neoplasms
  • Middle Aged
  • Male
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Aged