Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Rifampin soaking dacron-based endografts for implantation in infected aortic aneurysms--new application of a time-tested principle.

Publication ,  Journal Article
Escobar, GA; Eliason, JL; Hurie, J; Arya, S; Rectenwald, JE; Coleman, DM
Published in: Ann Vasc Surg
April 2014

Infections involving the aorta are associated with high rates of morbidity and mortality, and their management is complex. Saturating Dacron grafts in rifampin (60 mg/mL) inhibits the growth of organisms commonly found to be involved in both primary aortic infections and aortoenteric fistulas. Open repair and replacement of the aorta with rifampin-soaked Dacron grafts is frequently used in clinical practice and is considered a viable option for open repair with a low recurrence of infection; however, the morbidity and mortality of the procedure is significant. More recently, patients who are high risk for open surgery have been managed with endografts to treat infected aortas and aortoenteric fistulas with limited success, a high recurrence rate, and elevated mortality. We describe a technique to expose Dacron endografts with rifampin delivered via injection port or into the sheath before deployment in selected patients with aortic infections. We used this novel technique in 2 patients who were high risk for open repair: 1 with a bleeding aortoenteric fistula and 1 with mycotic abdominal aortic aneurysm. The first patient tolerated 1.5 years without surgical correction of the duodenal defect after placement of a rifampin-treated endograft. This allowed her to recover and ultimately undergo definitive repair under elective circumstances. Our second patient remains without evidence of recurrence 1 year after implantation for a mycotic abdominal aortic aneurysm. Following the principles of rifampin use in open vascular repairs, treating Dacron endografts with rifampin may add similar antimicrobial resistance when used to treat selected aortic infections.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Ann Vasc Surg

DOI

EISSN

1615-5947

Publication Date

April 2014

Volume

28

Issue

3

Start / End Page

744 / 748

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Tomography, X-Ray Computed
  • Rifampin
  • Prosthesis Design
  • Polyethylene Terephthalates
  • Humans
  • Female
  • Endovascular Procedures
  • Cardiovascular System & Hematology
  • Blood Vessel Prosthesis Implantation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Escobar, G. A., Eliason, J. L., Hurie, J., Arya, S., Rectenwald, J. E., & Coleman, D. M. (2014). Rifampin soaking dacron-based endografts for implantation in infected aortic aneurysms--new application of a time-tested principle. Ann Vasc Surg, 28(3), 744–748. https://doi.org/10.1016/j.avsg.2013.10.006
Escobar, Guillermo A., Jonathan L. Eliason, Justin Hurie, Shipra Arya, John E. Rectenwald, and Dawn M. Coleman. “Rifampin soaking dacron-based endografts for implantation in infected aortic aneurysms--new application of a time-tested principle.Ann Vasc Surg 28, no. 3 (April 2014): 744–48. https://doi.org/10.1016/j.avsg.2013.10.006.
Escobar GA, Eliason JL, Hurie J, Arya S, Rectenwald JE, Coleman DM. Rifampin soaking dacron-based endografts for implantation in infected aortic aneurysms--new application of a time-tested principle. Ann Vasc Surg. 2014 Apr;28(3):744–8.
Escobar, Guillermo A., et al. “Rifampin soaking dacron-based endografts for implantation in infected aortic aneurysms--new application of a time-tested principle.Ann Vasc Surg, vol. 28, no. 3, Apr. 2014, pp. 744–48. Pubmed, doi:10.1016/j.avsg.2013.10.006.
Escobar GA, Eliason JL, Hurie J, Arya S, Rectenwald JE, Coleman DM. Rifampin soaking dacron-based endografts for implantation in infected aortic aneurysms--new application of a time-tested principle. Ann Vasc Surg. 2014 Apr;28(3):744–748.
Journal cover image

Published In

Ann Vasc Surg

DOI

EISSN

1615-5947

Publication Date

April 2014

Volume

28

Issue

3

Start / End Page

744 / 748

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Tomography, X-Ray Computed
  • Rifampin
  • Prosthesis Design
  • Polyethylene Terephthalates
  • Humans
  • Female
  • Endovascular Procedures
  • Cardiovascular System & Hematology
  • Blood Vessel Prosthesis Implantation