Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer.
Publication
, Journal Article
Lee, E; Crowder, HR; Gorelik, D; Badger, C; Schottler, J; Li, N-W; Siegel, R; Sadeghi, N; Thakkar, PG; Joshi, AS; Goodman, JF
Published in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
September 2022
Platinum and taxane-based neoadjuvant chemotherapy with surgery (NAC + S) is a novel de-intensified treatment modality that is currently under investigation.All patients treated for HPV positive OPSCC with NAC + S at a single institution between 2006 and 2020 were contacted to complete the University of Washington Quality of life questionnaire (UW-QOL) at least 2 years following the completion of treatment.The UW-QOL surveys were received from 25 of 48 eligible patients (52.1%). The mean follow-up time was 4.3 years (range 2.0-7.6 years). The overall mean score for the physical subscale was 92.4 (Standard deviation, SD = 10.9), and the social-emotional subscale was 91.1 (11.8). Compared to the normative cohort, the NAC + S cohort had a worse appearance (Mean scores Normative vs. NAC + S: 93 vs. 84.0, p = 0.009).NAC + S offers favorable long-term QOL, as evidenced by near-normal scores in most QOL domains.
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Published In
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
DOI
EISSN
1434-4726
ISSN
0937-4477
Publication Date
September 2022
Volume
279
Issue
9
Start / End Page
4533 / 4540
Related Subject Headings
- Surveys and Questionnaires
- Quality of Life
- Otorhinolaryngology
- Oropharyngeal Neoplasms
- Humans
- Cohort Studies
- Carcinoma, Squamous Cell
- 3202 Clinical sciences
- 1103 Clinical Sciences
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MLA
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Lee, E., Crowder, H. R., Gorelik, D., Badger, C., Schottler, J., Li, N.-W., … Goodman, J. F. (2022). Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer. European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 279(9), 4533–4540. https://doi.org/10.1007/s00405-022-07387-7
Lee, Esther, Hannah R. Crowder, Daniel Gorelik, Christopher Badger, Jennifer Schottler, Ning-Wei Li, Robert Siegel, et al. “Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer.” European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 279, no. 9 (September 2022): 4533–40. https://doi.org/10.1007/s00405-022-07387-7.
Lee E, Crowder HR, Gorelik D, Badger C, Schottler J, Li N-W, et al. Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2022 Sep;279(9):4533–40.
Lee, Esther, et al. “Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer.” European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, vol. 279, no. 9, Sept. 2022, pp. 4533–40. Epmc, doi:10.1007/s00405-022-07387-7.
Lee E, Crowder HR, Gorelik D, Badger C, Schottler J, Li N-W, Siegel R, Sadeghi N, Thakkar PG, Joshi AS, Goodman JF. Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2022 Sep;279(9):4533–4540.
Published In
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
DOI
EISSN
1434-4726
ISSN
0937-4477
Publication Date
September 2022
Volume
279
Issue
9
Start / End Page
4533 / 4540
Related Subject Headings
- Surveys and Questionnaires
- Quality of Life
- Otorhinolaryngology
- Oropharyngeal Neoplasms
- Humans
- Cohort Studies
- Carcinoma, Squamous Cell
- 3202 Clinical sciences
- 1103 Clinical Sciences