Recurrent Cryptogenic Stroke in a Young Woman: Congenital Thrombotic Thrombocytopenic Purpura Unmasked
Publication
, Journal Article
Wanjiku, C; Wadi, LC; Shah, S; Onwuemene, OA
Published in: Annals of Internal Medicine Clinical Cases
December 1, 2022
Cryptogenic stroke of undetermined cause should warrant an exhaustive neurologic and cardiovascular workup. If no cause is identified, additional investigations should be individualized on the basis of clinical history and objective findings. Herein, we present the case of a young patient with a personal and family history of cryptogenic stroke who was investigated for thrombophilia. Transient thrombocytopenia and peripheral blood schistocytes led to an eventual diagnosis of congenital thrombotic thrombocytopenic purpura, which is characterized by vaso-occlusive end-organ complications. The diagnosis is confirmed by undetectable ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motifs, member 13) activity.
Duke Scholars
Published In
Annals of Internal Medicine Clinical Cases
DOI
EISSN
2767-7664
Publication Date
December 1, 2022
Volume
1
Issue
10
Citation
APA
Chicago
ICMJE
MLA
NLM
Wanjiku, C., Wadi, L. C., Shah, S., & Onwuemene, O. A. (2022). Recurrent Cryptogenic Stroke in a Young Woman: Congenital Thrombotic Thrombocytopenic Purpura Unmasked. Annals of Internal Medicine Clinical Cases, 1(10). https://doi.org/10.7326/aimcc.2022.0689
Wanjiku, C., L. C. Wadi, S. Shah, and O. A. Onwuemene. “Recurrent Cryptogenic Stroke in a Young Woman: Congenital Thrombotic Thrombocytopenic Purpura Unmasked.” Annals of Internal Medicine Clinical Cases 1, no. 10 (December 1, 2022). https://doi.org/10.7326/aimcc.2022.0689.
Wanjiku C, Wadi LC, Shah S, Onwuemene OA. Recurrent Cryptogenic Stroke in a Young Woman: Congenital Thrombotic Thrombocytopenic Purpura Unmasked. Annals of Internal Medicine Clinical Cases. 2022 Dec 1;1(10).
Wanjiku, C., et al. “Recurrent Cryptogenic Stroke in a Young Woman: Congenital Thrombotic Thrombocytopenic Purpura Unmasked.” Annals of Internal Medicine Clinical Cases, vol. 1, no. 10, Dec. 2022. Scopus, doi:10.7326/aimcc.2022.0689.
Wanjiku C, Wadi LC, Shah S, Onwuemene OA. Recurrent Cryptogenic Stroke in a Young Woman: Congenital Thrombotic Thrombocytopenic Purpura Unmasked. Annals of Internal Medicine Clinical Cases. 2022 Dec 1;1(10).
Published In
Annals of Internal Medicine Clinical Cases
DOI
EISSN
2767-7664
Publication Date
December 1, 2022
Volume
1
Issue
10