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Mechanisms underlying reshuffling of visual responses by optogenetic stimulation in mice and monkeys.

Publication ,  Journal Article
Sanzeni, A; Palmigiano, A; Nguyen, TH; Luo, J; Nassi, JJ; Reynolds, JH; Histed, MH; Miller, KD; Brunel, N
Published in: Neuron
December 20, 2023

The ability to optogenetically perturb neural circuits opens an unprecedented window into mechanisms governing circuit function. We analyzed and theoretically modeled neuronal responses to visual and optogenetic inputs in mouse and monkey V1. In both species, optogenetic stimulation of excitatory neurons strongly modulated the activity of single neurons yet had weak or no effects on the distribution of firing rates across the population. Thus, the optogenetic inputs reshuffled firing rates across the network. Key statistics of mouse and monkey responses lay on a continuum, with mice/monkeys occupying the low-/high-rate regions, respectively. We show that neuronal reshuffling emerges generically in randomly connected excitatory/inhibitory networks, provided the coupling strength (combination of recurrent coupling and external input) is sufficient that powerful inhibitory feedback cancels the mean optogenetic input. A more realistic model, distinguishing tuned visual vs. untuned optogenetic input in a structured network, reduces the coupling strength needed to explain reshuffling.

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Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

December 20, 2023

Volume

111

Issue

24

Start / End Page

4102 / 4115.e9

Location

United States

Related Subject Headings

  • Visual Cortex
  • Random Allocation
  • Photic Stimulation
  • Optogenetics
  • Neurons
  • Neurology & Neurosurgery
  • Mice
  • Haplorhini
  • Animals
  • 5202 Biological psychology
 

Citation

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Sanzeni, A., Palmigiano, A., Nguyen, T. H., Luo, J., Nassi, J. J., Reynolds, J. H., … Brunel, N. (2023). Mechanisms underlying reshuffling of visual responses by optogenetic stimulation in mice and monkeys. Neuron, 111(24), 4102-4115.e9. https://doi.org/10.1016/j.neuron.2023.09.018
Sanzeni, Alessandro, Agostina Palmigiano, Tuan H. Nguyen, Junxiang Luo, Jonathan J. Nassi, John H. Reynolds, Mark H. Histed, Kenneth D. Miller, and Nicolas Brunel. “Mechanisms underlying reshuffling of visual responses by optogenetic stimulation in mice and monkeys.Neuron 111, no. 24 (December 20, 2023): 4102-4115.e9. https://doi.org/10.1016/j.neuron.2023.09.018.
Sanzeni A, Palmigiano A, Nguyen TH, Luo J, Nassi JJ, Reynolds JH, et al. Mechanisms underlying reshuffling of visual responses by optogenetic stimulation in mice and monkeys. Neuron. 2023 Dec 20;111(24):4102-4115.e9.
Sanzeni, Alessandro, et al. “Mechanisms underlying reshuffling of visual responses by optogenetic stimulation in mice and monkeys.Neuron, vol. 111, no. 24, Dec. 2023, pp. 4102-4115.e9. Pubmed, doi:10.1016/j.neuron.2023.09.018.
Sanzeni A, Palmigiano A, Nguyen TH, Luo J, Nassi JJ, Reynolds JH, Histed MH, Miller KD, Brunel N. Mechanisms underlying reshuffling of visual responses by optogenetic stimulation in mice and monkeys. Neuron. 2023 Dec 20;111(24):4102-4115.e9.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

December 20, 2023

Volume

111

Issue

24

Start / End Page

4102 / 4115.e9

Location

United States

Related Subject Headings

  • Visual Cortex
  • Random Allocation
  • Photic Stimulation
  • Optogenetics
  • Neurons
  • Neurology & Neurosurgery
  • Mice
  • Haplorhini
  • Animals
  • 5202 Biological psychology