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HTPN 078: an enhanced case management study to achieve viral suppression among viremic HIV-positive men who have sex with men in the United States.

Publication ,  Journal Article
Remien, RH; Dacus, J-D; Farley, JE; Hughes, JP; Gamble, T; Wang, ZZ; Batey, DS; Mayer, KH; Del Rio, C; Balán, IC; Irvin, R; Mitchell, KM ...
Published in: AIDS
February 1, 2023

OBJECTIVES: After identifying and recruiting men who have sex with men living with HIV and virally unsuppressed, this study attempted to enhance treatment and care via case management to increase the proportion who achieved viral suppression. DESIGN: Participants were randomized into one of two study arms: standard of care (SOC) or enhanced case management (CM) intervention. Participants were followed for 12 months with quarterly study assessments, with blood collected for CD4+ cell count testing, HIV viral load testing (primary prespecified outcome), and plasma storage. METHODS: Participants identified via respondent-driven sampling and direct recruitment and were invited to participate in the randomized controlled trial. The CM intervention provided a wide range of support services including, health education, clinical care coordination, medication adherence support, and social service assistance. The month-12 assessment included questions about healthcare utilization, stigma, substance use, and mental health. RESULTS: Among the 144 participants virally unsuppressed at baseline, most had had a previous positive HIV test result; were Black, non-Hispanic, gay and bisexual men, aged 22-50. Among the 128 participants at the last study visit, 68 were virally suppressed, with no statistically significant difference between the CM and SOC arms (viral suppression 42% and 53%, respectively; adjusted odds ratio = 0.62 [P = 0.15; 95% confidence interval: 0.32, 1.2]). CONCLUSIONS: Reaching targets of at least 90% sustained viral suppression among all people with HIV will likely require more than an individual-level CM approach that addresses barriers to optimal care and treatment at multiple levels.

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Published In

AIDS

DOI

EISSN

1473-5571

Publication Date

February 1, 2023

Volume

37

Issue

2

Start / End Page

217 / 231

Location

England

Related Subject Headings

  • Virology
  • Viral Load
  • United States
  • Sexual and Gender Minorities
  • Medication Adherence
  • Male
  • Humans
  • Homosexuality, Male
  • HIV Infections
  • Case Management
 

Citation

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ICMJE
MLA
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Remien, R. H., Dacus, J.-D., Farley, J. E., Hughes, J. P., Gamble, T., Wang, Z. Z., … HPTN 078 Study Team, . (2023). HTPN 078: an enhanced case management study to achieve viral suppression among viremic HIV-positive men who have sex with men in the United States. AIDS, 37(2), 217–231. https://doi.org/10.1097/QAD.0000000000003411
Remien, Robert H., Jagadīśa-Devaśrī Dacus, Jason E. Farley, James P. Hughes, Theresa Gamble, Zhe Zoe Wang, D Scott Batey, et al. “HTPN 078: an enhanced case management study to achieve viral suppression among viremic HIV-positive men who have sex with men in the United States.AIDS 37, no. 2 (February 1, 2023): 217–31. https://doi.org/10.1097/QAD.0000000000003411.
Remien RH, Dacus J-D, Farley JE, Hughes JP, Gamble T, Wang ZZ, et al. HTPN 078: an enhanced case management study to achieve viral suppression among viremic HIV-positive men who have sex with men in the United States. AIDS. 2023 Feb 1;37(2):217–31.
Remien, Robert H., et al. “HTPN 078: an enhanced case management study to achieve viral suppression among viremic HIV-positive men who have sex with men in the United States.AIDS, vol. 37, no. 2, Feb. 2023, pp. 217–31. Pubmed, doi:10.1097/QAD.0000000000003411.
Remien RH, Dacus J-D, Farley JE, Hughes JP, Gamble T, Wang ZZ, Batey DS, Mayer KH, Del Rio C, Balán IC, Irvin R, Mitchell KM, Cummings V, Eshleman SH, Conserve DF, Knox J, Yu K, Beyrer C, HPTN 078 Study Team. HTPN 078: an enhanced case management study to achieve viral suppression among viremic HIV-positive men who have sex with men in the United States. AIDS. 2023 Feb 1;37(2):217–231.

Published In

AIDS

DOI

EISSN

1473-5571

Publication Date

February 1, 2023

Volume

37

Issue

2

Start / End Page

217 / 231

Location

England

Related Subject Headings

  • Virology
  • Viral Load
  • United States
  • Sexual and Gender Minorities
  • Medication Adherence
  • Male
  • Humans
  • Homosexuality, Male
  • HIV Infections
  • Case Management