Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women.
Publication
, Journal Article
Rahangdale, L; De Paris, K; Kashuba, ADM; Nelson, JAE; Cottrell, M; Sykes, C; Emerson, C; Young, SL; Stevens, T; Patterson, KB; Cohen, MS
Published in: J Acquir Immune Defic Syndr
April 1, 2015
: A comparative analysis of cellular and soluble markers of immune activation in HIV-infected women on combination antiretroviral therapy showed that the upper genital tract (UGT) compared to the lower female genital tract was characterized by higher frequencies of potential HIV target cells and increased inflammatory molecules. Despite the activated UGT milieu, HIV RNA could not be detected in paired samples of plasma, cervicovaginal or endometrial lavage. As antiretroviral concentrations were ≥3-fold higher in the endometrium than in the lower genital tract, high antiretroviral penetration and/or metabolism may limit viral replication in the UGT.
Duke Scholars
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Published In
J Acquir Immune Defic Syndr
DOI
EISSN
1944-7884
Publication Date
April 1, 2015
Volume
68
Issue
4
Start / End Page
420 / 424
Location
United States
Related Subject Headings
- Young Adult
- Virology
- Reproductive Tract Infections
- Middle Aged
- Humans
- HIV Infections
- Female
- Endometrium
- Anti-Retroviral Agents
- Adult
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Rahangdale, L., De Paris, K., Kashuba, A. D. M., Nelson, J. A. E., Cottrell, M., Sykes, C., … Cohen, M. S. (2015). Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women. J Acquir Immune Defic Syndr, 68(4), 420–424. https://doi.org/10.1097/QAI.0000000000000480
Rahangdale, Lisa, Kristina De Paris, Angela D. M. Kashuba, Julie A. E. Nelson, Mackenzie Cottrell, Craig Sykes, Cindi Emerson, et al. “Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women.” J Acquir Immune Defic Syndr 68, no. 4 (April 1, 2015): 420–24. https://doi.org/10.1097/QAI.0000000000000480.
Rahangdale L, De Paris K, Kashuba ADM, Nelson JAE, Cottrell M, Sykes C, et al. Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women. J Acquir Immune Defic Syndr. 2015 Apr 1;68(4):420–4.
Rahangdale, Lisa, et al. “Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women.” J Acquir Immune Defic Syndr, vol. 68, no. 4, Apr. 2015, pp. 420–24. Pubmed, doi:10.1097/QAI.0000000000000480.
Rahangdale L, De Paris K, Kashuba ADM, Nelson JAE, Cottrell M, Sykes C, Emerson C, Young SL, Stevens T, Patterson KB, Cohen MS. Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women. J Acquir Immune Defic Syndr. 2015 Apr 1;68(4):420–424.
Published In
J Acquir Immune Defic Syndr
DOI
EISSN
1944-7884
Publication Date
April 1, 2015
Volume
68
Issue
4
Start / End Page
420 / 424
Location
United States
Related Subject Headings
- Young Adult
- Virology
- Reproductive Tract Infections
- Middle Aged
- Humans
- HIV Infections
- Female
- Endometrium
- Anti-Retroviral Agents
- Adult