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Serum concentrations of enclomiphene and zuclomiphene across consecutive cycles of clomiphene citrate therapy in anovulatory infertile women.

Publication ,  Journal Article
Young, SL; Opsahl, MS; Fritz, MA
Published in: Fertil Steril
April 1999

OBJECTIVE: To determine the serum concentrations of enclomiphene and zuclomiphene across consecutive cycles of clomiphene citrate treatment in anovulatory infertile women. DESIGN: Prospective cohort. SETTING: Tertiary institutional infertility clinic. PATIENT(S): Fourteen consenting anovulatory infertile women receiving standardized, cyclic, incremental treatment with clomiphene citrate for ovulation induction. INTERVENTION(S): Clomiphene citrate treatment (50-150 mg/d, cycle days 5-9), titrated to the minimum effective ovulation-inducing dose, was administered for three to six total cycles. Blood samples were obtained on cycle days 3 and 10 in each treatment cycle. MAIN OUTCOME MEASURE(S): Serum concentrations of enclomiphene and zuclomiphene. RESULT(S): Cycle day 3 zuclomiphene levels were below assay limits in all initial cycles, increased progressively across three consecutive cycles, and thereafter plateaued. Cycle day 3 enclomiphene concentrations were uniformly undetectable. Cycle day 10 enclomiphene levels increased with dose administered, but these observations were not statistically significant. CONCLUSION(S): Clomiphene citrate induction of ovulation results in an isomer-specific systemic accumulation of zuclomiphene across consecutive cycles of treatment. The combined maximum concentration of enclomiphene and zuclomiphene attained in practice approximates 100 nmol/L and is generally well below levels previously demonstrated to have adverse effects in vitro.

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Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

April 1999

Volume

71

Issue

4

Start / End Page

639 / 644

Location

United States

Related Subject Headings

  • Prospective Studies
  • Ovulation Induction
  • Obstetrics & Reproductive Medicine
  • Infertility, Female
  • Humans
  • Fertility Agents, Female
  • Female
  • Enclomiphene
  • Cohort Studies
  • Clomiphene
 

Citation

APA
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Young, S. L., Opsahl, M. S., & Fritz, M. A. (1999). Serum concentrations of enclomiphene and zuclomiphene across consecutive cycles of clomiphene citrate therapy in anovulatory infertile women. Fertil Steril, 71(4), 639–644. https://doi.org/10.1016/s0015-0282(98)00537-8
Young, S. L., M. S. Opsahl, and M. A. Fritz. “Serum concentrations of enclomiphene and zuclomiphene across consecutive cycles of clomiphene citrate therapy in anovulatory infertile women.Fertil Steril 71, no. 4 (April 1999): 639–44. https://doi.org/10.1016/s0015-0282(98)00537-8.
Young, S. L., et al. “Serum concentrations of enclomiphene and zuclomiphene across consecutive cycles of clomiphene citrate therapy in anovulatory infertile women.Fertil Steril, vol. 71, no. 4, Apr. 1999, pp. 639–44. Pubmed, doi:10.1016/s0015-0282(98)00537-8.
Journal cover image

Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

April 1999

Volume

71

Issue

4

Start / End Page

639 / 644

Location

United States

Related Subject Headings

  • Prospective Studies
  • Ovulation Induction
  • Obstetrics & Reproductive Medicine
  • Infertility, Female
  • Humans
  • Fertility Agents, Female
  • Female
  • Enclomiphene
  • Cohort Studies
  • Clomiphene