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A Novel Device to Prevent Stone Fragment Migration During Percutaneous Lithotripsy: Results from an In Vitro Kidney Model.

Publication ,  Journal Article
Antonelli, JA; Beardsley, H; Faddegon, S; Morgan, MSC; Gahan, JC; Pearle, MS; Cadeddu, JA
Published in: J Endourol
November 2016

PURPOSE: We developed a polyethylene sack (the PercSac) that fits over the shaft of a rigid nephroscope and is deployed into the collecting system to capture a stone and contain fragments during percutaneous nephrolithotomy (PCNL). We previously reported our results using the PercSac in a percutaneous cystolithopaxy model. In this study, we compare the efficiency of stone fragmentation with and without the PercSac in an anatomically correct in vitro PCNL model. MATERIALS AND METHODS: The PCNL model consisted of a human collecting system model created on a 3D printer. Ten BegoStones made in spherical molds of 2.0 cm diameter, matched for weight, were fragmented in the model using a 24F rigid nephroscope and an ultrasonic lithotripter, including five with and five without the PercSac. The total times for stone fragmentation and complete stone clearance, gross assessment of the stone-free status, and need for flexible nephroscopy to achieve a stone-free state were recorded. RESULTS: The median time for stone fragmentation was significantly shorter in the PercSac group compared with the control group (217 seconds [IQR = 169-255] vs 340 seconds [IQR = 310-356], [p = 0.028]). Likewise, the total time for complete stone clearance from the kidney was significantly shorter for the PercSac group (293 seconds [IQR = 244-347] vs 376 seconds [IQR = 375-480], [p = 0.047]). In one trial with the PercSac, residual dust remained in the kidney, while in all five trials without the PercSac small residual fragments remained. All trials without the PercSac required flexible nephroscopy with basket extraction to become stone free, while none of the trials with the PercSac required flexible nephroscopy for stone clearance. CONCLUSIONS: Ultrasonic lithotripsy using the novel PercSac stone entrapment device is more efficient and efficacious than traditional ultrasonic lithotripsy in an in vitro PCNL model. The advantage may be even more pronounced during clinical PCNL where residual fragments migrate into difficult-to-access calices. Further in vivo testing is underway.

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Published In

J Endourol

DOI

EISSN

1557-900X

Publication Date

November 2016

Volume

30

Issue

11

Start / End Page

1239 / 1243

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Ultrasonics
  • Treatment Outcome
  • Printing, Three-Dimensional
  • Polyethylene
  • Nephrostomy, Percutaneous
  • Models, Anatomic
  • Lithotripsy
  • Laparoscopy
  • Kidney Calculi
 

Citation

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Antonelli, J. A., Beardsley, H., Faddegon, S., Morgan, M. S. C., Gahan, J. C., Pearle, M. S., & Cadeddu, J. A. (2016). A Novel Device to Prevent Stone Fragment Migration During Percutaneous Lithotripsy: Results from an In Vitro Kidney Model. J Endourol, 30(11), 1239–1243. https://doi.org/10.1089/end.2016.0466
Antonelli, Jodi A., Heather Beardsley, Stephen Faddegon, Monica S. C. Morgan, Jeffrey C. Gahan, Margaret S. Pearle, and Jeffrey A. Cadeddu. “A Novel Device to Prevent Stone Fragment Migration During Percutaneous Lithotripsy: Results from an In Vitro Kidney Model.J Endourol 30, no. 11 (November 2016): 1239–43. https://doi.org/10.1089/end.2016.0466.
Antonelli JA, Beardsley H, Faddegon S, Morgan MSC, Gahan JC, Pearle MS, et al. A Novel Device to Prevent Stone Fragment Migration During Percutaneous Lithotripsy: Results from an In Vitro Kidney Model. J Endourol. 2016 Nov;30(11):1239–43.
Antonelli, Jodi A., et al. “A Novel Device to Prevent Stone Fragment Migration During Percutaneous Lithotripsy: Results from an In Vitro Kidney Model.J Endourol, vol. 30, no. 11, Nov. 2016, pp. 1239–43. Pubmed, doi:10.1089/end.2016.0466.
Antonelli JA, Beardsley H, Faddegon S, Morgan MSC, Gahan JC, Pearle MS, Cadeddu JA. A Novel Device to Prevent Stone Fragment Migration During Percutaneous Lithotripsy: Results from an In Vitro Kidney Model. J Endourol. 2016 Nov;30(11):1239–1243.
Journal cover image

Published In

J Endourol

DOI

EISSN

1557-900X

Publication Date

November 2016

Volume

30

Issue

11

Start / End Page

1239 / 1243

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Ultrasonics
  • Treatment Outcome
  • Printing, Three-Dimensional
  • Polyethylene
  • Nephrostomy, Percutaneous
  • Models, Anatomic
  • Lithotripsy
  • Laparoscopy
  • Kidney Calculi