In-vitro release studies of ciprofloxacin drug using polyaniline/polypyrrole-encapsulated β-cyclodextrin nanocomposites

The present study reports the synthesis of nanocomposites of β-cyclodextrin (β-CD) with polyaniline (PANI) and polypyrrole (PPy) to design core–shell nanocomposites. The synthesized nanocomposites were investigated for their spectral, morphological and thermal characteristics. IR spectra confirmed the incorporation of PANI and PPy in β-CD by the strong interaction between NH of PANI/PPY and OH of β-CD, while the ultraviolet (UV)-visible spectra confirmed the polaronic state of conducting polymers in the nanocomposites. The scanning electron microscopy (SEM) analysis revealed the core–shell like morphology of the nanocomposites. Ciprofloxacin (CIP) was chosen as a model drug to study the in-vitro drug release as gastric (pH 1.2) and intestinal (pH 7.4) values by loading the drug (50 mg) into the pristine polymers as well as β-CD nanocomposites. The nanocomposites were found to show the sustained release behavior and hold potential to be used as an effective antibiotic drug delivery vehicle.

Duke Scholars

Author Darlene Kimber Taylor Obstetrics and Gynecology