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An analysis of the outcomes of Clostridioides difficile occurring in intestinal transplant recipients requiring hospitalization.

Publication ,  Journal Article
Amjad, W; Schiano, T; Segovia, MC; Malik, A; Weiner, J; Horslen, S; Jafri, S-M
Published in: Transpl Infect Dis
February 2023

BACKGROUND: Organ transplantation is a known risk factor for Clostridioides difficile infection (CDI). There is limited published data on the impact of CDI in the intestinal transplant population. METHODS: We utilized the National Readmission Database (2010-2017) to study the outcomes of CDI in patients having a history of intestinal transplantation. Association of CDI with readmission and hospital resource utilization was computed in multivariable models adjusted for demographics and comorbidities. RESULTS: During 2010-2017, 8442 hospitalizations with the history of intestinal transplantation had indexed hospital admissions. Of these, 320 (3.8%) had CDI. CDI hospitalization in intestine transplant patients was associated with higher median cost $54 430 (IQR: 27 231, 109 980) as compared to patients who did not have CDI $48 888 (IQR: 22 578, 112 777), (β: 71 814 95% confidence intervals [CI]: 676-142 953, p = .048). The median length of stay was also longer for patients with CDI 7 (IQR: 4, 13) days as compared to 5 (IQR: 3, 11) days in non-CDI (β: 5.51 95% CI: 0.73-10.29, p = .02). The mortality rate, intestinal transplant complications, presence of malnutrition, acute kidney injury, ICU admissions, and sepsis were similar in both groups. CDI was the top cause of 30-day readmission in the intestinal transplant recipients with CDI during the index admission; the number of 30-day readmissions also increased from 2010 to 2017. CONCLUSION: CDI hospitalization in post-intestine transplant patients occurs commonly and is associated with a longer length of stay and higher costs during hospitalization. The CDI was the most common cause of readmission after the index admission of CDI in these patients.

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Published In

Transpl Infect Dis

DOI

EISSN

1399-3062

Publication Date

February 2023

Volume

25

Issue

1

Start / End Page

e13951

Location

Denmark

Related Subject Headings

  • Transplant Recipients
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Intestines
  • Humans
  • Hospitalization
  • Clostridium Infections
  • Clostridioides difficile
  • Clostridioides
 

Citation

APA
Chicago
ICMJE
MLA
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Amjad, W., Schiano, T., Segovia, M. C., Malik, A., Weiner, J., Horslen, S., & Jafri, S.-M. (2023). An analysis of the outcomes of Clostridioides difficile occurring in intestinal transplant recipients requiring hospitalization. Transpl Infect Dis, 25(1), e13951. https://doi.org/10.1111/tid.13951
Amjad, Waseem, Thomas Schiano, Maria C. Segovia, Adnan Malik, Joshua Weiner, Simon Horslen, and Syed-Mohammed Jafri. “An analysis of the outcomes of Clostridioides difficile occurring in intestinal transplant recipients requiring hospitalization.Transpl Infect Dis 25, no. 1 (February 2023): e13951. https://doi.org/10.1111/tid.13951.
Amjad W, Schiano T, Segovia MC, Malik A, Weiner J, Horslen S, et al. An analysis of the outcomes of Clostridioides difficile occurring in intestinal transplant recipients requiring hospitalization. Transpl Infect Dis. 2023 Feb;25(1):e13951.
Amjad, Waseem, et al. “An analysis of the outcomes of Clostridioides difficile occurring in intestinal transplant recipients requiring hospitalization.Transpl Infect Dis, vol. 25, no. 1, Feb. 2023, p. e13951. Pubmed, doi:10.1111/tid.13951.
Amjad W, Schiano T, Segovia MC, Malik A, Weiner J, Horslen S, Jafri S-M. An analysis of the outcomes of Clostridioides difficile occurring in intestinal transplant recipients requiring hospitalization. Transpl Infect Dis. 2023 Feb;25(1):e13951.
Journal cover image

Published In

Transpl Infect Dis

DOI

EISSN

1399-3062

Publication Date

February 2023

Volume

25

Issue

1

Start / End Page

e13951

Location

Denmark

Related Subject Headings

  • Transplant Recipients
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Intestines
  • Humans
  • Hospitalization
  • Clostridium Infections
  • Clostridioides difficile
  • Clostridioides