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Communication from the Scientific Standardization Committees of the International Society on Thrombosis and Haemostasis on vascular endothelium-related biomarkers in disseminated intravascular coagulation.

Publication ,  Journal Article
Iba, T; Levy, JH; Thachil, J; Susen, S; Levi, M; Scarlatescu, E
Published in: J Thromb Haemost
March 2023

Disseminated intravascular coagulation (DIC) is not a disease criterion but a pathomechanistic process that accompanies various underlying diseases. According to the International Society on Thrombosis and Haemostasis definition, endothelial injury is an essential component in addition to systemic coagulation activation. Despite this definition, current diagnostic criteria for DIC do not include biomarkers for vascular endothelial injury. Endothelial cells are critical for hemostatic regulation because they produce various antithrombotic substances and express anticoagulant factors at the same time as facilitating coagulation, inflammatory reactions, platelet aggregation, and fibrinolysis with acute injury. Endothelial cells also exhibit various receptors, adhesion molecules, and the critical role of glycocalyx that regulates cellular interactions in thromboinflammation. For clinicians, biomarkers suitable for assessing endothelial injury are not readily available. Although we still do not have ideal biomarkers, antithrombin activity and von Willebrand factor can be candidates for the endothelium-related markers because those reflect the severity and are available in most clinical settings. Further, the dysfunction of endothelial cell in DIC arising from various underlying diseases is likely highly variable. For example, the involvement of endothelial dysfunction is significant in sepsis-induced coagulopathy, while moderate in trauma-induced coagulopathy, and variable in hematologic malignancy-associated coagulopathy. Because of the complexity of disease status associated with DIC, further research searching clinically available endothelium-related biomarkers is expected to establish individualized diagnostic criteria and potential therapeutic approaches.

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Published In

J Thromb Haemost

DOI

EISSN

1538-7836

Publication Date

March 2023

Volume

21

Issue

3

Start / End Page

691 / 699

Location

England

Related Subject Headings

  • Thrombosis
  • Sepsis
  • Inflammation
  • Humans
  • Hemostasis
  • Endothelium, Vascular
  • Endothelial Cells
  • Disseminated Intravascular Coagulation
  • Communication
  • Cardiovascular System & Hematology
 

Citation

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Iba, T., Levy, J. H., Thachil, J., Susen, S., Levi, M., & Scarlatescu, E. (2023). Communication from the Scientific Standardization Committees of the International Society on Thrombosis and Haemostasis on vascular endothelium-related biomarkers in disseminated intravascular coagulation. J Thromb Haemost, 21(3), 691–699. https://doi.org/10.1016/j.jtha.2022.11.032
Iba, Toshiaki, Jerrold H. Levy, Jecko Thachil, Sophie Susen, Marcel Levi, and Ecaterina Scarlatescu. “Communication from the Scientific Standardization Committees of the International Society on Thrombosis and Haemostasis on vascular endothelium-related biomarkers in disseminated intravascular coagulation.J Thromb Haemost 21, no. 3 (March 2023): 691–99. https://doi.org/10.1016/j.jtha.2022.11.032.
Journal cover image

Published In

J Thromb Haemost

DOI

EISSN

1538-7836

Publication Date

March 2023

Volume

21

Issue

3

Start / End Page

691 / 699

Location

England

Related Subject Headings

  • Thrombosis
  • Sepsis
  • Inflammation
  • Humans
  • Hemostasis
  • Endothelium, Vascular
  • Endothelial Cells
  • Disseminated Intravascular Coagulation
  • Communication
  • Cardiovascular System & Hematology