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Annual Research Review: Prenatal opioid exposure - a two-generation approach to conceptualizing neurodevelopmental outcomes.

Publication ,  Journal Article
Conradt, E; Camerota, M; Maylott, S; Lester, BM
Published in: J Child Psychol Psychiatry
April 2023

Opioid use during pregnancy impacts the health and well-being of two generations: the pregnant person and the child. The factors that increase risk for opioid use in the adult, as well as those that perpetuate risk for the caregiver and child, oftentimes replicate across generations and may be more likely to affect child neurodevelopment than the opioid exposure itself. In this article, we review the prenatal opioid exposure literature with the perspective that this is not a singular event but an intergenerational cascade of events. We highlight several mechanisms of transmission across generations: biological factors, including genetics and epigenetics and the gut-brain axis; parent-child mechanisms, such as prepregnancy experience of child maltreatment, quality of parenting, infant behaviors, neonatal opioid withdrawal diagnosis, and broader environmental contributors including poverty, violence exposure, stigma, and Child Protective Services involvement. We conclude by describing ways in which intergenerational transmission can be disrupted by early intervention.

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Published In

J Child Psychol Psychiatry

DOI

EISSN

1469-7610

Publication Date

April 2023

Volume

64

Issue

4

Start / End Page

566 / 578

Location

England

Related Subject Headings

  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Poverty
  • Parenting
  • Infant, Newborn
  • Infant Behavior
  • Infant
  • Humans
  • Female
  • Developmental & Child Psychology
 

Citation

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ICMJE
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Conradt, E., Camerota, M., Maylott, S., & Lester, B. M. (2023). Annual Research Review: Prenatal opioid exposure - a two-generation approach to conceptualizing neurodevelopmental outcomes. J Child Psychol Psychiatry, 64(4), 566–578. https://doi.org/10.1111/jcpp.13761
Conradt, Elisabeth, Marie Camerota, Sarah Maylott, and Barry M. Lester. “Annual Research Review: Prenatal opioid exposure - a two-generation approach to conceptualizing neurodevelopmental outcomes.J Child Psychol Psychiatry 64, no. 4 (April 2023): 566–78. https://doi.org/10.1111/jcpp.13761.
Conradt E, Camerota M, Maylott S, Lester BM. Annual Research Review: Prenatal opioid exposure - a two-generation approach to conceptualizing neurodevelopmental outcomes. J Child Psychol Psychiatry. 2023 Apr;64(4):566–78.
Conradt, Elisabeth, et al. “Annual Research Review: Prenatal opioid exposure - a two-generation approach to conceptualizing neurodevelopmental outcomes.J Child Psychol Psychiatry, vol. 64, no. 4, Apr. 2023, pp. 566–78. Pubmed, doi:10.1111/jcpp.13761.
Conradt E, Camerota M, Maylott S, Lester BM. Annual Research Review: Prenatal opioid exposure - a two-generation approach to conceptualizing neurodevelopmental outcomes. J Child Psychol Psychiatry. 2023 Apr;64(4):566–578.
Journal cover image

Published In

J Child Psychol Psychiatry

DOI

EISSN

1469-7610

Publication Date

April 2023

Volume

64

Issue

4

Start / End Page

566 / 578

Location

England

Related Subject Headings

  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Poverty
  • Parenting
  • Infant, Newborn
  • Infant Behavior
  • Infant
  • Humans
  • Female
  • Developmental & Child Psychology