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Cytomegalovirus Infection Management in Multivisceral and Intestinal Transplant: A Dual Institution Study.

Publication ,  Journal Article
Currier, EE; Ichkanian, Y; Dabaja, M; Segovia, MC; Patel, Y; Nagai, S; Sudan, DL; Jafri, S-M
Published in: Transplant Proc
March 2023

Intestinal transplant and multivisceral transplant were originally in pediatric populations and are relatively new procedures in adults. Despite increasing success rates in the immediate post-transplant period, infectious complications and acute and chronic rejection remain significant causes of morbidity and mortality. Previous research has shown cytomegalovirus (CMV) is the main cause of infection in this population. Due to the limited patient population, incidence of CMV viremia ranges widely and there is lack of universal protocol for treatment. This dual institution retrospective chart review between Henry Ford Hospital and Duke University analyzed adult intestinal and multivisceral transplant recipients between 2009 and 2019. Of the 32 patients identified and included in the study, 15 had CMV infection (46.9%). Of those with CMV infection, 5 (33.3%) had donor positive (D+)/recipient positive (R+) status; 5 had D-/R+; 4 had D+/R-; and one had D-/R-. There was no significant difference between mortality in those who had reported infection and not (80% vs 76.5%). The data from this study show significant rates of CMV viremia in patients undergoing intestinal transplant/multivisceral transplant with almost half of our study population having documented infection within 1 year of transplant, stressing the importance for universal protocol into CMV viremia treatment.

Duke Scholars

Published In

Transplant Proc

DOI

EISSN

1873-2623

Publication Date

March 2023

Volume

55

Issue

2

Start / End Page

413 / 416

Location

United States

Related Subject Headings

  • Viremia
  • Transplant Recipients
  • Retrospective Studies
  • Humans
  • Cytomegalovirus Infections
  • Cytomegalovirus
  • Child
  • Antiviral Agents
  • Adult
  • 3204 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Currier, E. E., Ichkanian, Y., Dabaja, M., Segovia, M. C., Patel, Y., Nagai, S., … Jafri, S.-M. (2023). Cytomegalovirus Infection Management in Multivisceral and Intestinal Transplant: A Dual Institution Study. Transplant Proc, 55(2), 413–416. https://doi.org/10.1016/j.transproceed.2023.01.014
Currier, Emily E., Yervant Ichkanian, Mohamad Dabaja, Maria Cristina Segovia, Yuval Patel, Shunji Nagai, Debra L. Sudan, and Syed-Mohammed Jafri. “Cytomegalovirus Infection Management in Multivisceral and Intestinal Transplant: A Dual Institution Study.Transplant Proc 55, no. 2 (March 2023): 413–16. https://doi.org/10.1016/j.transproceed.2023.01.014.
Currier EE, Ichkanian Y, Dabaja M, Segovia MC, Patel Y, Nagai S, et al. Cytomegalovirus Infection Management in Multivisceral and Intestinal Transplant: A Dual Institution Study. Transplant Proc. 2023 Mar;55(2):413–6.
Currier, Emily E., et al. “Cytomegalovirus Infection Management in Multivisceral and Intestinal Transplant: A Dual Institution Study.Transplant Proc, vol. 55, no. 2, Mar. 2023, pp. 413–16. Pubmed, doi:10.1016/j.transproceed.2023.01.014.
Currier EE, Ichkanian Y, Dabaja M, Segovia MC, Patel Y, Nagai S, Sudan DL, Jafri S-M. Cytomegalovirus Infection Management in Multivisceral and Intestinal Transplant: A Dual Institution Study. Transplant Proc. 2023 Mar;55(2):413–416.
Journal cover image

Published In

Transplant Proc

DOI

EISSN

1873-2623

Publication Date

March 2023

Volume

55

Issue

2

Start / End Page

413 / 416

Location

United States

Related Subject Headings

  • Viremia
  • Transplant Recipients
  • Retrospective Studies
  • Humans
  • Cytomegalovirus Infections
  • Cytomegalovirus
  • Child
  • Antiviral Agents
  • Adult
  • 3204 Immunology