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The association of prenatal phthalates, organophosphorous pesticides, and organophosphate esters with early child language ability in Norway.

Publication ,  Journal Article
Ramos, AM; Herring, AH; Villanger, GD; Thomsen, C; Sakhi, AK; Cequier, E; Aase, H; Engel, SM
Published in: Environmental research
May 2023

Prenatal exposure to phthalates, organophosphate esters, and organophosphorous pesticides have been associated with neurodevelopmental deficits including language ability, however, few studies consider the effect of exposure mixtures and the potential longitudinal detriments over time.This study examines the influence of prenatal exposure to phthalates, organophosphate esters, and organophosphorous pesticides, on children's language ability from toddlerhood to the preschool period.This study includes 299 mother-child dyads from Norway in the Norwegian Mother, Father and Child Cohort Study (MoBa). Prenatal exposure to chemicals were assessed at 17 weeks' gestation, and child language skills were assessed at 18 months using the Ages and Stages Questionnaire communication subscale and at preschool age using the Child Development Inventory. We ran two structural equation models to examine the simultaneous influences of chemical exposures on parent-reported and teacher-reported child language ability.Prenatal organophosphorous pesticides were negatively associated with preschool language ability through language ability at 18 months. Additionally, there was a negative association between low molecular weight phthalates and teacher-reported preschool language ability. There was no effect of prenatal organophosphate esters on child language ability at either 18 months or preschool age.This study adds to the literature on prenatal exposure to chemicals and neurodevelopment and highlights the importance of developmental pathways in early childhood.

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Published In

Environmental research

DOI

EISSN

1096-0953

ISSN

0013-9351

Publication Date

May 2023

Volume

225

Start / End Page

115508

Related Subject Headings

  • Toxicology
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Pesticides
  • Organophosphates
  • Norway
  • Humans
  • Female
  • Cohort Studies
  • Child, Preschool
 

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Ramos, A. M., Herring, A. H., Villanger, G. D., Thomsen, C., Sakhi, A. K., Cequier, E., … Engel, S. M. (2023). The association of prenatal phthalates, organophosphorous pesticides, and organophosphate esters with early child language ability in Norway. Environmental Research, 225, 115508. https://doi.org/10.1016/j.envres.2023.115508
Ramos, Amanda M., Amy H. Herring, Gro D. Villanger, Cathrine Thomsen, Amrit K. Sakhi, Enrique Cequier, Heidi Aase, and Stephanie M. Engel. “The association of prenatal phthalates, organophosphorous pesticides, and organophosphate esters with early child language ability in Norway.Environmental Research 225 (May 2023): 115508. https://doi.org/10.1016/j.envres.2023.115508.
Ramos AM, Herring AH, Villanger GD, Thomsen C, Sakhi AK, Cequier E, et al. The association of prenatal phthalates, organophosphorous pesticides, and organophosphate esters with early child language ability in Norway. Environmental research. 2023 May;225:115508.
Ramos, Amanda M., et al. “The association of prenatal phthalates, organophosphorous pesticides, and organophosphate esters with early child language ability in Norway.Environmental Research, vol. 225, May 2023, p. 115508. Epmc, doi:10.1016/j.envres.2023.115508.
Ramos AM, Herring AH, Villanger GD, Thomsen C, Sakhi AK, Cequier E, Aase H, Engel SM. The association of prenatal phthalates, organophosphorous pesticides, and organophosphate esters with early child language ability in Norway. Environmental research. 2023 May;225:115508.
Journal cover image

Published In

Environmental research

DOI

EISSN

1096-0953

ISSN

0013-9351

Publication Date

May 2023

Volume

225

Start / End Page

115508

Related Subject Headings

  • Toxicology
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Pesticides
  • Organophosphates
  • Norway
  • Humans
  • Female
  • Cohort Studies
  • Child, Preschool