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Guanylyl cyclase C ameliorates visceral pain: an unsuspected link.

Publication ,  Journal Article
Liddle, RA
Published in: J Clin Invest
February 15, 2023

Visceral pain associated with irritable bowel syndrome afflicts 15% of the US population. Although treatments are limited, guanylyl cyclase C (GUCY2C) agonists alleviate pain and constipation. Until now, it was assumed that the activation of GUCY2C and production of cGMP in enterocytes stimulated fluid secretion and reduced visceral sensation. The recent discovery that a subtype of enteroendocrine cells (EECs) known as neuropod cells synapse with submucosal neurons unveiled a pathway for communicating gut signals to the nervous system. In this issue of the JCI, Barton et al. report that GUCY2C is enriched in neuropod cells and is involved with sensory nerve firing. Selective deletion of GUCY2C in mouse models suggests that defective GUCY2C neuropod-cell signaling underlies visceral pain. These studies introduce possibilities for dissociating the secretory and analgesic effects of GUCY2C agonism. Although further work remains, unveiling the role of neuropod cells is a major step in understanding visceral pain.

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Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

February 15, 2023

Volume

133

Issue

4

Location

United States

Related Subject Headings

  • Visceral Pain
  • Signal Transduction
  • Receptors, Enterotoxin
  • Mice
  • Irritable Bowel Syndrome
  • Immunology
  • Cyclic GMP
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
 

Citation

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MLA
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Liddle, R. A. (2023). Guanylyl cyclase C ameliorates visceral pain: an unsuspected link. J Clin Invest, 133(4). https://doi.org/10.1172/JCI166703
Liddle, Rodger A. “Guanylyl cyclase C ameliorates visceral pain: an unsuspected link.J Clin Invest 133, no. 4 (February 15, 2023). https://doi.org/10.1172/JCI166703.
Liddle RA. Guanylyl cyclase C ameliorates visceral pain: an unsuspected link. J Clin Invest. 2023 Feb 15;133(4).
Liddle, Rodger A. “Guanylyl cyclase C ameliorates visceral pain: an unsuspected link.J Clin Invest, vol. 133, no. 4, Feb. 2023. Pubmed, doi:10.1172/JCI166703.
Liddle RA. Guanylyl cyclase C ameliorates visceral pain: an unsuspected link. J Clin Invest. 2023 Feb 15;133(4).

Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

February 15, 2023

Volume

133

Issue

4

Location

United States

Related Subject Headings

  • Visceral Pain
  • Signal Transduction
  • Receptors, Enterotoxin
  • Mice
  • Irritable Bowel Syndrome
  • Immunology
  • Cyclic GMP
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences