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Early treatment response as predictor of long-term outcome in a clinical cohort of children with ADHD.

Publication ,  Journal Article
Houmann, TB; Kaalund-Brok, K; Clemmensen, L; Petersen, MA; Plessen, KJ; Bilenberg, N; Verhulst, F; Jeppesen, P; INDICES,
Published in: Eur Child Adolesc Psychiatry
February 2024

This study investigates early onset of treatment response as predictor of symptomatic and functional outcome 3 years after initiation of methylphenidate (MPH) administration in a naturalistic, clinical cohort of children and adolescents with ADHD. Children were followed across an initial 12-week MPH treatment trial and after 3 years, with ratings of symptoms and impairment. Associations between a clinically significant MPH treatment response in week 3 (defined as ≥ 20% reduction in clinician-rated symptoms) and in week 12 (defined as ≥ 40% reduction), and 3-year outcome were tested in multivariate linear regression models, adjusting for sex, age, comorbidity, IQ, maternal education, parental psychiatric disorder, and baseline symptoms and function. We did not have information on treatment adherence or the nature of treatments beyond 12 weeks. 148 children, mean age 12.4 years (range 10-16 years), 77% males, participated in the follow-up. We found a significant decrease in symptom score from baseline [M = 41.9 (SD = 13.2)] to 3-year follow-up [M = 27.5 (SD = 12.7), p < 0.001, and in impairment score from baseline (M = 41.6 (SD = 19.4)] to 3-year follow-up [M = 35.6 (SD = 20.2), p = 0.005]. Treatment responses in week 3 and week 12 were significant predictors of the long-term outcome of symptoms, but not of impairment at 3-year follow-up, when adjusting for other well-known predictors. Early treatment response predicts long-term outcome over and above other well-known predictors. Clinicians should follow-up patients carefully, during the first months of treatment, and detect non-responders, since there might be a window of opportunity to alter the outcome, by changing the treatment strategy.Clinical trial registration: ClinicalTrials.gov, registration number NCT04366609, April 28, 2020 retrospectively registered.

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Published In

Eur Child Adolesc Psychiatry

DOI

EISSN

1435-165X

Publication Date

February 2024

Volume

33

Issue

2

Start / End Page

357 / 367

Location

Germany

Related Subject Headings

  • Treatment Outcome
  • Methylphenidate
  • Male
  • Humans
  • Female
  • Developmental & Child Psychology
  • Cognition
  • Child
  • Central Nervous System Stimulants
  • Attention Deficit Disorder with Hyperactivity
 

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Houmann, T. B., Kaalund-Brok, K., Clemmensen, L., Petersen, M. A., Plessen, K. J., Bilenberg, N., … INDICES, . (2024). Early treatment response as predictor of long-term outcome in a clinical cohort of children with ADHD. Eur Child Adolesc Psychiatry, 33(2), 357–367. https://doi.org/10.1007/s00787-023-02158-z
Houmann, Tine Bodil, Kristine Kaalund-Brok, Lars Clemmensen, Morten Aagaard Petersen, Kerstin Jessica Plessen, Niels Bilenberg, Frank Verhulst, Pia Jeppesen, and Pia INDICES. “Early treatment response as predictor of long-term outcome in a clinical cohort of children with ADHD.Eur Child Adolesc Psychiatry 33, no. 2 (February 2024): 357–67. https://doi.org/10.1007/s00787-023-02158-z.
Houmann TB, Kaalund-Brok K, Clemmensen L, Petersen MA, Plessen KJ, Bilenberg N, et al. Early treatment response as predictor of long-term outcome in a clinical cohort of children with ADHD. Eur Child Adolesc Psychiatry. 2024 Feb;33(2):357–67.
Houmann, Tine Bodil, et al. “Early treatment response as predictor of long-term outcome in a clinical cohort of children with ADHD.Eur Child Adolesc Psychiatry, vol. 33, no. 2, Feb. 2024, pp. 357–67. Pubmed, doi:10.1007/s00787-023-02158-z.
Houmann TB, Kaalund-Brok K, Clemmensen L, Petersen MA, Plessen KJ, Bilenberg N, Verhulst F, Jeppesen P, INDICES. Early treatment response as predictor of long-term outcome in a clinical cohort of children with ADHD. Eur Child Adolesc Psychiatry. 2024 Feb;33(2):357–367.
Journal cover image

Published In

Eur Child Adolesc Psychiatry

DOI

EISSN

1435-165X

Publication Date

February 2024

Volume

33

Issue

2

Start / End Page

357 / 367

Location

Germany

Related Subject Headings

  • Treatment Outcome
  • Methylphenidate
  • Male
  • Humans
  • Female
  • Developmental & Child Psychology
  • Cognition
  • Child
  • Central Nervous System Stimulants
  • Attention Deficit Disorder with Hyperactivity