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Associations Between Thinner Retinal Neuronal Layers and Suboptimal Brain Structural Integrity in a Middle-Aged Cohort.

Publication ,  Journal Article
Barrett-Young, A; Abraham, WC; Cheung, CY; Gale, J; Hogan, S; Ireland, D; Keenan, R; Knodt, AR; Melzer, TR; Moffitt, TE; Ramrakha, S; Tham, YC ...
Published in: Eye and brain
January 2023

The retina has potential as a biomarker of brain health and Alzheimer's disease (AD) because it is the only part of the central nervous system which can be easily imaged and has advantages over brain imaging technologies. Few studies have compared retinal and brain measurements in a middle-aged sample. The objective of our study was to investigate whether retinal neuronal measurements were associated with structural brain measurements in a middle-aged population-based cohort.Participants were members of the Dunedin Multidisciplinary Health and Development Study (n=1037; a longitudinal cohort followed from birth and at ages 3, 5, 7, 9, 11, 13, 15, 18, 21, 26, 32, 38, and most recently at age 45, when 94% of the living Study members participated). Retinal nerve fibre layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) thickness were measured by optical coherence tomography (OCT). Brain age gap estimate (brainAGE), cortical surface area, cortical thickness, subcortical grey matter volumes, white matter hyperintensities, were measured by magnetic resonance imaging (MRI).Participants with both MRI and OCT data were included in the analysis (RNFL n=828, female n=413 [49.9%], male n=415 [50.1%]; GC-IPL n=825, female n=413 [50.1%], male n=412 [49.9%]). Thinner retinal neuronal layers were associated with older brain age, smaller cortical surface area, thinner average cortex, smaller subcortical grey matter volumes, and increased volume of white matter hyperintensities.These findings provide evidence that the retinal neuronal layers reflect differences in midlife structural brain integrity consistent with increased risk for later AD, supporting the proposition that the retina may be an early biomarker of brain health.

Duke Scholars

Published In

Eye and brain

DOI

EISSN

1179-2744

ISSN

1179-2744

Publication Date

January 2023

Volume

15

Start / End Page

25 / 35

Related Subject Headings

  • 3212 Ophthalmology and optometry
  • 3209 Neurosciences
  • 1113 Opthalmology and Optometry
  • 1109 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Barrett-Young, A., Abraham, W. C., Cheung, C. Y., Gale, J., Hogan, S., Ireland, D., … Poulton, R. (2023). Associations Between Thinner Retinal Neuronal Layers and Suboptimal Brain Structural Integrity in a Middle-Aged Cohort. Eye and Brain, 15, 25–35. https://doi.org/10.2147/eb.s402510
Barrett-Young, Ashleigh, Wickliffe C. Abraham, Carol Y. Cheung, Jesse Gale, Sean Hogan, David Ireland, Ross Keenan, et al. “Associations Between Thinner Retinal Neuronal Layers and Suboptimal Brain Structural Integrity in a Middle-Aged Cohort.Eye and Brain 15 (January 2023): 25–35. https://doi.org/10.2147/eb.s402510.
Barrett-Young A, Abraham WC, Cheung CY, Gale J, Hogan S, Ireland D, et al. Associations Between Thinner Retinal Neuronal Layers and Suboptimal Brain Structural Integrity in a Middle-Aged Cohort. Eye and brain. 2023 Jan;15:25–35.
Barrett-Young, Ashleigh, et al. “Associations Between Thinner Retinal Neuronal Layers and Suboptimal Brain Structural Integrity in a Middle-Aged Cohort.Eye and Brain, vol. 15, Jan. 2023, pp. 25–35. Epmc, doi:10.2147/eb.s402510.
Barrett-Young A, Abraham WC, Cheung CY, Gale J, Hogan S, Ireland D, Keenan R, Knodt AR, Melzer TR, Moffitt TE, Ramrakha S, Tham YC, Wilson GA, Wong TY, Hariri AR, Poulton R. Associations Between Thinner Retinal Neuronal Layers and Suboptimal Brain Structural Integrity in a Middle-Aged Cohort. Eye and brain. 2023 Jan;15:25–35.

Published In

Eye and brain

DOI

EISSN

1179-2744

ISSN

1179-2744

Publication Date

January 2023

Volume

15

Start / End Page

25 / 35

Related Subject Headings

  • 3212 Ophthalmology and optometry
  • 3209 Neurosciences
  • 1113 Opthalmology and Optometry
  • 1109 Neurosciences