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Critically dysregulated signaling pathways and clinical utility of the pathway biomarkers in lymphoid malignancies

Publication ,  Journal Article
Sun, RF; Yu, QQ; Young, KH
Published in: Chronic Diseases and Translational Medicine
March 1, 2018

Accumulating evidence confirmed that many dysregulated signaling pathways and aberrant genetic alterations contribute to the oncogenesis and heterogeneity of lymphoid malignancies. Therapeutically targeting dysregulating signaling pathways and their hidden oncogenic biomarkers are becoming available, but did not show desired therapeutic effect in current clinical practice. It is meaningful to further understand the underlying mechanisms of the dysregulated signaling pathways and to address the potential utility of pathway-related biomarkers. To precisely identify the dysregulation of signaling pathways and the “driver” oncogenic biomarkers, as well as to develop reliable and reproducible risk-stratification based on biomarkers will be challenging. Nevertheless, pathway-based targeted therapy will raise the hope to improve the outcomes of the patients with lymphoid malignancies, especially with aggressive types, and the efficient utility of pathway-related biomarkers in diagnosis, prognosis, prediction of lymphoid malignancies may also be able to power precision medicine.

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Published In

Chronic Diseases and Translational Medicine

DOI

EISSN

2095-882X

Publication Date

March 1, 2018

Volume

4

Issue

1

Start / End Page

29 / 44
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sun, R. F., Yu, Q. Q., & Young, K. H. (2018). Critically dysregulated signaling pathways and clinical utility of the pathway biomarkers in lymphoid malignancies. Chronic Diseases and Translational Medicine, 4(1), 29–44. https://doi.org/10.1016/j.cdtm.2018.02.001

Published In

Chronic Diseases and Translational Medicine

DOI

EISSN

2095-882X

Publication Date

March 1, 2018

Volume

4

Issue

1

Start / End Page

29 / 44