Variant prostate carcinoma and elevated serum CA-125.
INTRODUCTION: About 10% of tumors derived from nongynecologic, noncoelomic tissues react with the OC125 antibody. Some patients with advanced prostate cancer were found to have elevated serum CA-125 level. MATERIALS AND METHODS: We examined the clinical history of 11 patients with castration resistant prostate cancer and an elevated serum CA-125 level. Pathological review and immunohistochemical staining were performed on tumors from eight of these patients. RESULTS: Patients with advanced prostate cancer and an elevated serum CA-125 level responded to androgen ablative therapy (median duration, 27 months). They were predisposed to develop persistent or recurrent urinary symptoms and visceral metastases. Eight of 11 patients had a low or undetectable serum prostate-specific antigen level (≤ 4 ng/mL) or an elevated serum carcinoembryonic antigen level (> 6 ng/mL). In 3 of 7 patients whose specimens were available for further review, the tumors contained histologic features compatible with a diagnosis of ductal or endometrioid adenocarcinoma of the prostate. CONCLUSIONS: Patients with prostate cancer and an elevated serum CA-125 level have unique clinical and pathologic characteristics. Some of these patients possess tumors compatible with a subtype of prostate cancer known as ductal adenocarcinoma. Additional studies need to be performed to elucidate the biologic basis of the various subtypes of prostate cancer.
Duke Scholars
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Related Subject Headings
- Survival Rate
- Prostatic Neoplasms, Castration-Resistant
- Prostate-Specific Antigen
- Neoplasm Grading
- Middle Aged
- Male
- Immunohistochemistry
- Humans
- Carcinoembryonic Antigen
- CA-125 Antigen
Citation
Published In
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Survival Rate
- Prostatic Neoplasms, Castration-Resistant
- Prostate-Specific Antigen
- Neoplasm Grading
- Middle Aged
- Male
- Immunohistochemistry
- Humans
- Carcinoembryonic Antigen
- CA-125 Antigen