
Dynamic Opposition of Histone Modifications.
Publication
, Journal Article
Garzón-Porras, AM; Chory, E; Gryder, BE
Published in: ACS chemical biology
April 2023
Gene transcription does not only require writers of active histone modifications; on-site opposition by erasers is essential for many genes. Here, we propose the concept of dynamic opposition of histone modifications to explain this conundrum. We highlight the requirement of HDACs for acetylation balance at superenhancers, and the requirement of KDM5A for H4K3me3 recycling at highly active gene promoters. We propose that histone post-translational modifications regulate charge balance for biomolecular condensate formation and nucleosome turnover and form a short-term memory that informs lock-and-step checkpoints for chromatin engagement by RNA polymerase II.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
ACS chemical biology
DOI
EISSN
1554-8937
ISSN
1554-8929
Publication Date
April 2023
Volume
18
Issue
4
Start / End Page
1027 / 1036
Related Subject Headings
- Protein Processing, Post-Translational
- Organic Chemistry
- Nucleosomes
- Histones
- Histone Code
- Chromatin
- Acetylation
- 34 Chemical sciences
- 31 Biological sciences
- 06 Biological Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Garzón-Porras, A. M., Chory, E., & Gryder, B. E. (2023). Dynamic Opposition of Histone Modifications. ACS Chemical Biology, 18(4), 1027–1036. https://doi.org/10.1021/acschembio.1c01000
Garzón-Porras, Ana María, Emma Chory, and Berkley E. Gryder. “Dynamic Opposition of Histone Modifications.” ACS Chemical Biology 18, no. 4 (April 2023): 1027–36. https://doi.org/10.1021/acschembio.1c01000.
Garzón-Porras AM, Chory E, Gryder BE. Dynamic Opposition of Histone Modifications. ACS chemical biology. 2023 Apr;18(4):1027–36.
Garzón-Porras, Ana María, et al. “Dynamic Opposition of Histone Modifications.” ACS Chemical Biology, vol. 18, no. 4, Apr. 2023, pp. 1027–36. Epmc, doi:10.1021/acschembio.1c01000.
Garzón-Porras AM, Chory E, Gryder BE. Dynamic Opposition of Histone Modifications. ACS chemical biology. 2023 Apr;18(4):1027–1036.

Published In
ACS chemical biology
DOI
EISSN
1554-8937
ISSN
1554-8929
Publication Date
April 2023
Volume
18
Issue
4
Start / End Page
1027 / 1036
Related Subject Headings
- Protein Processing, Post-Translational
- Organic Chemistry
- Nucleosomes
- Histones
- Histone Code
- Chromatin
- Acetylation
- 34 Chemical sciences
- 31 Biological sciences
- 06 Biological Sciences