Scholars@Duke

RNAi libraries and kinetoplast DNA

Publication ,  Journal Article
Englund, PT; Agbo, EEC; Lindsay, ME; Liu, B; Liu, Y; Motyka, SA; Yildirir, G; Zhao, Z
Published in: Biochemical Society Transactions
October 26, 2005
Published version (DOI) Publisher Link

African trypanosomes have a remarkable mitochondrial DNA termed kDNA (kinetoplast DNA) that contains several thousands of topologically interlocked DNA rings. Because of its highly unusual structure, kDNA has a complex replication mechanism. Our approach to understanding this mechanism is to identify the proteins involved and to characterize their function. So far approx. 30 candidate proteins have been discovered and we predict that there are over 100. To identify genes for more kDNA replication proteins, we are using an RNA interference library, which is the first forward genetic approach used for these parasites.

Duke Scholars

Beiyu Liu
Author Beiyu Liu  

Published In

Biochemical Society Transactions

DOI

10.1042/bst0331409

EISSN

1470-8752

ISSN

0300-5127

Publication Date

October 26, 2005

Volume

33

Issue

6

Start / End Page

1409 / 1412

Publisher

Portland Press Ltd.

Related Subject Headings

  • Biochemistry & Molecular Biology
  • 3101 Biochemistry and cell biology
  • 1101 Medical Biochemistry and Metabolomics
  • 0601 Biochemistry and Cell Biology
 

Citation

APA
Chicago
ICMJE
MLA
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Englund, P. T., Agbo, E. E. C., Lindsay, M. E., Liu, B., Liu, Y., Motyka, S. A., … Zhao, Z. (2005). RNAi libraries and kinetoplast DNA. Biochemical Society Transactions, 33(6), 1409–1412. https://doi.org/10.1042/bst0331409
Englund, P. T., E. E. C. Agbo, M. E. Lindsay, B. Liu, Y. Liu, S. A. Motyka, G. Yildirir, and Z. Zhao. “RNAi libraries and kinetoplast DNA.” Biochemical Society Transactions 33, no. 6 (October 26, 2005): 1409–12. https://doi.org/10.1042/bst0331409.
Englund PT, Agbo EEC, Lindsay ME, Liu B, Liu Y, Motyka SA, et al. RNAi libraries and kinetoplast DNA. Biochemical Society Transactions. 2005 Oct 26;33(6):1409–12.
Englund, P. T., et al. “RNAi libraries and kinetoplast DNA.” Biochemical Society Transactions, vol. 33, no. 6, Portland Press Ltd., Oct. 2005, pp. 1409–12. Crossref, doi:10.1042/bst0331409.
Englund PT, Agbo EEC, Lindsay ME, Liu B, Liu Y, Motyka SA, Yildirir G, Zhao Z. RNAi libraries and kinetoplast DNA. Biochemical Society Transactions. Portland Press Ltd.; 2005 Oct 26;33(6):1409–1412.

Published In

Biochemical Society Transactions

DOI

10.1042/bst0331409

EISSN

1470-8752

ISSN

0300-5127

Publication Date

October 26, 2005

Volume

33

Issue

6

Start / End Page

1409 / 1412

Publisher

Portland Press Ltd.

Related Subject Headings

  • Biochemistry & Molecular Biology
  • 3101 Biochemistry and cell biology
  • 1101 Medical Biochemistry and Metabolomics
  • 0601 Biochemistry and Cell Biology