Does congenital cytomegalovirus infection contribute to the development of acute lymphoblastic leukemia in children?
Publication
, Journal Article
Toor, RK; Semmes, EC; Walsh, KM; Permar, SR; Giulino-Roth, L
Published in: Curr Opin Virol
June 2023
Cytomegalovirus (CMV) is a ubiquitous herpesvirus that has a profound impact on the host immune system. Congenital cytomegalovirus (cCMV) infection modulates neonatal immune cell compartments, yet the full impact of in utero exposure on developing fetal immune cells remains poorly characterized. A series of recent studies have identified a potential link between cCMV infection and the development of acute lymphoblastic leukemia (ALL) in childhood. Here, we review the emerging evidence linking CMV and ALL risk, discuss what is known about the causes of childhood ALL, and propose how CMV infection in early life may confer increased ALL risk.
Duke Scholars
Published In
Curr Opin Virol
DOI
EISSN
1879-6265
Publication Date
June 2023
Volume
60
Start / End Page
101325
Location
Netherlands
Related Subject Headings
- Risk Factors
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Infant, Newborn
- Immunomodulation
- Humans
- Cytomegalovirus Infections
- Child
- 3107 Microbiology
- 1108 Medical Microbiology
- 0605 Microbiology
Citation
APA
Chicago
ICMJE
MLA
NLM
Toor, R. K., Semmes, E. C., Walsh, K. M., Permar, S. R., & Giulino-Roth, L. (2023). Does congenital cytomegalovirus infection contribute to the development of acute lymphoblastic leukemia in children? Curr Opin Virol, 60, 101325. https://doi.org/10.1016/j.coviro.2023.101325
Toor, Rajbir K., Eleanor C. Semmes, Kyle M. Walsh, Sallie R. Permar, and Lisa Giulino-Roth. “Does congenital cytomegalovirus infection contribute to the development of acute lymphoblastic leukemia in children?” Curr Opin Virol 60 (June 2023): 101325. https://doi.org/10.1016/j.coviro.2023.101325.
Toor RK, Semmes EC, Walsh KM, Permar SR, Giulino-Roth L. Does congenital cytomegalovirus infection contribute to the development of acute lymphoblastic leukemia in children? Curr Opin Virol. 2023 Jun;60:101325.
Toor, Rajbir K., et al. “Does congenital cytomegalovirus infection contribute to the development of acute lymphoblastic leukemia in children?” Curr Opin Virol, vol. 60, June 2023, p. 101325. Pubmed, doi:10.1016/j.coviro.2023.101325.
Toor RK, Semmes EC, Walsh KM, Permar SR, Giulino-Roth L. Does congenital cytomegalovirus infection contribute to the development of acute lymphoblastic leukemia in children? Curr Opin Virol. 2023 Jun;60:101325.
Published In
Curr Opin Virol
DOI
EISSN
1879-6265
Publication Date
June 2023
Volume
60
Start / End Page
101325
Location
Netherlands
Related Subject Headings
- Risk Factors
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Infant, Newborn
- Immunomodulation
- Humans
- Cytomegalovirus Infections
- Child
- 3107 Microbiology
- 1108 Medical Microbiology
- 0605 Microbiology