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Improved reconstruction stability for chemical shift encoded hyperpolarized 13 C magnetic resonance spectroscopic imaging using k-t spiral acquisitions.

Publication ,  Journal Article
Macdonald, EB; Barton, GP; Cox, BL; Johnson, KM; Strigel, RM; Fain, SB
Published in: Magnetic resonance in medicine
July 2020

A multiecho, field of view (FOV)-oversampled k-t spiral acquisition and direct iterative decomposition of water and fat with echo asymmetry and least-squares estimation reconstruction is demonstrated to improve the stability of hyperpolarized 13 C magnetic resonance spectroscopic imaging (MRSI) in the presence of signal ambiguities attributed to low-SNR (signal-to-noise-ratio) species, local uncertainties in metabolite peaks, and echo-to-echo signal inconsistencies.k-t spiral acquisitions redistribute readout points to be more densely spaced radially in k-space by acquiring an FOV and matrix that are oversampled by η. These more densely spaced spiral turns constitute effective intraspiral echoes and can supplement conventional interspiral echoes to improve spectral separation and reduce spectral cross-talk to better resolve 13 C-labeled species for spectroscopic imaging.Digital simulations and imaging phantom experiments were performed for a range of interspiral echo spacings and η using multiecho, k-t spiral acquisitions. Image spectral cross-talk artifacts were evaluated both qualitatively and quantitatively as the percent error in measured metabolite ratios. In vivo murine experiments evaluated the feasibility of multiecho, k-t spiral [1-13 C]pyruvate MRSI to reduce spectral cross-talk for 3 scenarios of different expected reconstruction stability.Digital simulations and imaging phantom experiments both demonstrated reduced or comparable image spectral cross-talk and percent errors in measured metabolite ratios with increasing η and better choices of echo spacings. In vivo images displayed markedly reduced spectral cross-talk in lactate images acquired with η = 7 versus η = 1.The precision of hyperpolarized 13 C metabolic imaging and quantification in the presence of low-SNR species, local uncertainties in metabolite resonances, and echo-to-echo signal inconsistencies can be improved with the use of FOV-oversampled k-t spiral acquisitions.

Duke Scholars

Published In

Magnetic resonance in medicine

DOI

EISSN

1522-2594

ISSN

0740-3194

Publication Date

July 2020

Volume

84

Issue

1

Start / End Page

25 / 38

Related Subject Headings

  • Pyruvic Acid
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Mice
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Carbon Isotopes
  • Animals
  • Algorithms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Macdonald, E. B., Barton, G. P., Cox, B. L., Johnson, K. M., Strigel, R. M., & Fain, S. B. (2020). Improved reconstruction stability for chemical shift encoded hyperpolarized 13 C magnetic resonance spectroscopic imaging using k-t spiral acquisitions. Magnetic Resonance in Medicine, 84(1), 25–38. https://doi.org/10.1002/mrm.28122
Journal cover image

Published In

Magnetic resonance in medicine

DOI

EISSN

1522-2594

ISSN

0740-3194

Publication Date

July 2020

Volume

84

Issue

1

Start / End Page

25 / 38

Related Subject Headings

  • Pyruvic Acid
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Mice
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Carbon Isotopes
  • Animals
  • Algorithms