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Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1.

Publication ,  Journal Article
Jiménez, B; Volpert, OV; Crawford, SE; Febbraio, M; Silverstein, RL; Bouck, N
Published in: Nat Med
January 2000

Thrombospondin-1 (TSP-1) is a naturally occurring inhibitor of angiogenesis that limits vessel density in normal tissues and curtails tumor growth. Here, we show that the inhibition of angiogenesis in vitro and in vivo and the induction of apoptosis by thrombospondin-1 all required the sequential activation of CD36, p59fyn, caspase-3 like proteases and p38 mitogen-activated protein kinases. We also detected increased endothelial cell apoptosis in situ at the margins of tumors in mice treated with thrombospondin-1. These results indicate that thrombospondin-1, and possibly other broad-spectrum natural inhibitors of angiogenesis, act in vivo by inducing receptor-mediated apoptosis in activated microvascular endothelial cells.

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Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

January 2000

Volume

6

Issue

1

Start / End Page

41 / 48

Location

United States

Related Subject Headings

  • p38 Mitogen-Activated Protein Kinases
  • Thrombospondin 1
  • Signal Transduction
  • Proto-Oncogene Proteins c-fyn
  • Proto-Oncogene Proteins
  • Protein-Tyrosine Kinases
  • Plasminogen
  • Peptide Fragments
  • Neovascularization, Physiologic
  • Neovascularization, Pathologic
 

Citation

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Jiménez, B., Volpert, O. V., Crawford, S. E., Febbraio, M., Silverstein, R. L., & Bouck, N. (2000). Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. Nat Med, 6(1), 41–48. https://doi.org/10.1038/71517
Jiménez, B., O. V. Volpert, S. E. Crawford, M. Febbraio, R. L. Silverstein, and N. Bouck. “Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1.Nat Med 6, no. 1 (January 2000): 41–48. https://doi.org/10.1038/71517.
Jiménez B, Volpert OV, Crawford SE, Febbraio M, Silverstein RL, Bouck N. Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. Nat Med. 2000 Jan;6(1):41–8.
Jiménez, B., et al. “Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1.Nat Med, vol. 6, no. 1, Jan. 2000, pp. 41–48. Pubmed, doi:10.1038/71517.
Jiménez B, Volpert OV, Crawford SE, Febbraio M, Silverstein RL, Bouck N. Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. Nat Med. 2000 Jan;6(1):41–48.

Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

January 2000

Volume

6

Issue

1

Start / End Page

41 / 48

Location

United States

Related Subject Headings

  • p38 Mitogen-Activated Protein Kinases
  • Thrombospondin 1
  • Signal Transduction
  • Proto-Oncogene Proteins c-fyn
  • Proto-Oncogene Proteins
  • Protein-Tyrosine Kinases
  • Plasminogen
  • Peptide Fragments
  • Neovascularization, Physiologic
  • Neovascularization, Pathologic