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Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance

Publication ,  Journal Article
Liu, C; Cai, Z; Jin, G; Peng, D; Pan, B-S; Zhang, X; Han, F; Xu, X; Lin, H-K
Published in: Cell Discovery
October 2, 2018

The century-old embryonal/gametogenesis hypothesis of tumors could link diverse tumors’ malignant features together likely representing the real “stemness” of tumors. However, the genetic evidence to validate abnormal gametogenesis in tumors remains lacking. Here we show that p53 deficiency elicits abnormal gametogenesis from primordial germ cell-like stage to late oocyte-like stage and subsequent parthenogenetic activation. The similar upregulation of abnormal gametogenesis by p53 deficiency is observed both in p53 mouse model and cultured cancer cells. Notably, germ cell-like cells isolated from distinct tumors from p53 mice and cancer cell lines display potent tumorigenicity potential. Abnormal oogenesis induced by p53 deficiency and then spontaneous parthenogenetic activation endow tumors with imitated embryonic development, life cycle, and therapeutic resistance. Our study establishes the genetic evidence to support embryonal/gametogenesis theory of tumors and reveals a pivotal role of p53 in restricting abnormal gametogenesis that may represent a novel aspect for p53’s tumor suppression.

Duke Scholars

Published In

Cell Discovery

DOI

EISSN

2056-5968

Publication Date

October 2, 2018

Volume

4

Issue

1

Publisher

Springer Science and Business Media LLC

Related Subject Headings

  • 0601 Biochemistry and Cell Biology
 

Citation

APA
Chicago
ICMJE
MLA
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Liu, C., Cai, Z., Jin, G., Peng, D., Pan, B.-S., Zhang, X., … Lin, H.-K. (2018). Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance. Cell Discovery, 4(1). https://doi.org/10.1038/s41421-018-0054-x
Liu, Chunfang, Zhen Cai, Guoxiang Jin, Danni Peng, Bo-Syong Pan, Xian Zhang, Fei Han, Xiaohong Xu, and Hui-Kuan Lin. “Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance.” Cell Discovery 4, no. 1 (October 2, 2018). https://doi.org/10.1038/s41421-018-0054-x.
Liu C, Cai Z, Jin G, Peng D, Pan B-S, Zhang X, et al. Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance. Cell Discovery. 2018 Oct 2;4(1).
Liu, Chunfang, et al. “Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance.” Cell Discovery, vol. 4, no. 1, Springer Science and Business Media LLC, Oct. 2018. Crossref, doi:10.1038/s41421-018-0054-x.
Liu C, Cai Z, Jin G, Peng D, Pan B-S, Zhang X, Han F, Xu X, Lin H-K. Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance. Cell Discovery. Springer Science and Business Media LLC; 2018 Oct 2;4(1).

Published In

Cell Discovery

DOI

EISSN

2056-5968

Publication Date

October 2, 2018

Volume

4

Issue

1

Publisher

Springer Science and Business Media LLC

Related Subject Headings

  • 0601 Biochemistry and Cell Biology