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AMPK signaling and its targeting in cancer progression and treatment.

Publication ,  Journal Article
Hsu, C-C; Peng, D; Cai, Z; Lin, H-K
Published in: Semin Cancer Biol
October 2022

The intrinsic mechanisms sensing the imbalance of energy in cells are pivotal for cell survival under various environmental insults. AMP-activated protein kinase (AMPK) serves as a central guardian maintaining energy homeostasis by orchestrating diverse cellular processes, such as lipogenesis, glycolysis, TCA cycle, cell cycle progression and mitochondrial dynamics. Given that AMPK plays an essential role in the maintenance of energy balance and metabolism, managing AMPK activation is considered as a promising strategy for the treatment of metabolic disorders such as type 2 diabetes and obesity. Since AMPK has been attributed to aberrant activation of metabolic pathways, mitochondrial dynamics and functions, and epigenetic regulation, which are hallmarks of cancer, targeting AMPK may open up a new avenue for cancer therapies. Although AMPK is previously thought to be involved in tumor suppression, several recent studies have unraveled its tumor promoting activity. The double-edged sword characteristics for AMPK as a tumor suppressor or an oncogene are determined by distinct cellular contexts. In this review, we will summarize recent progress in dissecting the upstream regulators and downstream effectors for AMPK, discuss the distinct roles of AMPK in cancer regulation and finally offer potential strategies with AMPK targeting in cancer therapy.

Duke Scholars

Published In

Semin Cancer Biol

DOI

EISSN

1096-3650

Publication Date

October 2022

Volume

85

Start / End Page

52 / 68

Location

England

Related Subject Headings

  • Signal Transduction
  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Epigenesis, Genetic
  • Energy Metabolism
  • AMP-Activated Protein Kinases
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis
 

Citation

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MLA
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Hsu, C.-C., Peng, D., Cai, Z., & Lin, H.-K. (2022). AMPK signaling and its targeting in cancer progression and treatment. Semin Cancer Biol, 85, 52–68. https://doi.org/10.1016/j.semcancer.2021.04.006
Hsu, Che-Chia, Danni Peng, Zhen Cai, and Hui-Kuan Lin. “AMPK signaling and its targeting in cancer progression and treatment.Semin Cancer Biol 85 (October 2022): 52–68. https://doi.org/10.1016/j.semcancer.2021.04.006.
Hsu C-C, Peng D, Cai Z, Lin H-K. AMPK signaling and its targeting in cancer progression and treatment. Semin Cancer Biol. 2022 Oct;85:52–68.
Hsu, Che-Chia, et al. “AMPK signaling and its targeting in cancer progression and treatment.Semin Cancer Biol, vol. 85, Oct. 2022, pp. 52–68. Pubmed, doi:10.1016/j.semcancer.2021.04.006.
Hsu C-C, Peng D, Cai Z, Lin H-K. AMPK signaling and its targeting in cancer progression and treatment. Semin Cancer Biol. 2022 Oct;85:52–68.
Journal cover image

Published In

Semin Cancer Biol

DOI

EISSN

1096-3650

Publication Date

October 2022

Volume

85

Start / End Page

52 / 68

Location

England

Related Subject Headings

  • Signal Transduction
  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Epigenesis, Genetic
  • Energy Metabolism
  • AMP-Activated Protein Kinases
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis