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Ankle Osteoarthritis.

Publication ,  Journal Article
Godoy-Santos, AL; Fonseca, LF; de Cesar Netto, C; Giordano, V; Valderrabano, V; Rammelt, S
Published in: Rev Bras Ortop (Sao Paulo)
December 2021

Osteoarthritis (OA) is characterized by a chronic, progressive and irreversible degradation of the joint surface associated with joint inflammation. The main etiology of ankle OA is post-traumatic and its prevalence is higher among young and obese people. Despite advances in the treatment of fractures around the ankle, the overall risk of developing post-traumatic ankle OA after 20 years is almost 40%, especially in Weber type B and C bimalleolar fractures and in fractures involving the posterior tibial border. In talus fractures, this prevalence approaches 100%, depending on the severity of the lesion and the time of follow-up. In this context, the current understanding of the molecular signaling pathways involved in senescence and chondrocyte apoptosis is fundamental. The treatment of ankle OA is staged and guided by the classification systems and local and patient conditions. The main problems are the limited ability to regenerate articular cartilage, low blood supply, and a shortage of progenitor stem cells. The present update summarizes recent scientific evidence of post-traumatic ankle OA with a major focus on changes of the synovia, cartilage and synovial fluid; as well as the epidemiology, pathophysiology, clinical implications, treatment options and potential targets for therapeutic agents.

Duke Scholars

Published In

Rev Bras Ortop (Sao Paulo)

DOI

ISSN

0102-3616

Publication Date

December 2021

Volume

56

Issue

6

Start / End Page

689 / 696

Location

Germany

Related Subject Headings

  • Orthopedics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Godoy-Santos, A. L., Fonseca, L. F., de Cesar Netto, C., Giordano, V., Valderrabano, V., & Rammelt, S. (2021). Ankle Osteoarthritis. Rev Bras Ortop (Sao Paulo), 56(6), 689–696. https://doi.org/10.1055/s-0040-1709733
Godoy-Santos, Alexandre Leme, Lucas Furtado Fonseca, Cesar de Cesar Netto, Vincenzo Giordano, Victor Valderrabano, and Stefan Rammelt. “Ankle Osteoarthritis.Rev Bras Ortop (Sao Paulo) 56, no. 6 (December 2021): 689–96. https://doi.org/10.1055/s-0040-1709733.
Godoy-Santos AL, Fonseca LF, de Cesar Netto C, Giordano V, Valderrabano V, Rammelt S. Ankle Osteoarthritis. Rev Bras Ortop (Sao Paulo). 2021 Dec;56(6):689–96.
Godoy-Santos, Alexandre Leme, et al. “Ankle Osteoarthritis.Rev Bras Ortop (Sao Paulo), vol. 56, no. 6, Dec. 2021, pp. 689–96. Pubmed, doi:10.1055/s-0040-1709733.
Godoy-Santos AL, Fonseca LF, de Cesar Netto C, Giordano V, Valderrabano V, Rammelt S. Ankle Osteoarthritis. Rev Bras Ortop (Sao Paulo). 2021 Dec;56(6):689–696.
Journal cover image

Published In

Rev Bras Ortop (Sao Paulo)

DOI

ISSN

0102-3616

Publication Date

December 2021

Volume

56

Issue

6

Start / End Page

689 / 696

Location

Germany

Related Subject Headings

  • Orthopedics