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ERα PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study.

Publication ,  Journal Article
Pontin, PA; Nogara, PRB; Fonseca, FCP; Cesar Netto, C; Carvalho, KC; Soares Junior, JM; Baracat, EC; Fernandes, TD; Maffulli, N; Santos, MCL ...
Published in: J Orthop Surg Res
December 11, 2018

BACKGROUND: Posterior tibial tendon (PTT) insufficiency is considered as the main cause of adult acquired flat foot and is three times more frequent in females. High estrogen levels exert a positive effect on the overall collagen synthesis in tendons. We have previously demonstrated the association between some genetic single-nucleotide polymorphism (SNP) and tendinopathy. In the present study, we investigated the association of PvuII c454-397T>C (NCBI ID: rs2234693) and XbaI c454-351A>G (NCBI ID: rs9340799) SNPs in estrogen receptor alfa (ER-α) gene with PPT dysfunction. METHODS: A total of 92 female subjects with PTT dysfunction, with histopathological examination of the tendon and magnetic resonance image (MRI) evidence of tendinopathy, were compared to 92 asymptomatic females who presented an intact PPT at MRI for PvuII and XbaI SNPs in the ER-α gene. Genomic DNA was extracted from saliva and genotypes were obtained by polymerase chain reaction restriction fragment length polymorphism. RESULTS: The analysis of PvuII SNPs showed no significant differences in the frequency of alleles and genotypes between control and PTT dysfunction groups. The XbaI SNPs in the ER-α gene showed significant differences in the frequency of genotypes between control and test groups (p = 0.01; OR 95% 1.14 (0.55-2.33). CONCLUSIONS: The XbaI SNP in the ERα gene may contribute to tendinopathy, and the A/A genotype could be a risk factor for PTT tendinopathy in this population. The PvuII SNP studied was not associated with PTT tendinopathy.

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Published In

J Orthop Surg Res

DOI

EISSN

1749-799X

Publication Date

December 11, 2018

Volume

13

Issue

1

Start / End Page

316

Location

England

Related Subject Headings

  • Postmenopause
  • Posterior Tibial Tendon Dysfunction
  • Polymorphism, Single Nucleotide
  • Orthopedics
  • Middle Aged
  • Humans
  • Genetic Association Studies
  • Female
  • Estrogen Receptor alpha
  • Cross-Sectional Studies
 

Citation

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Pontin, P. A., Nogara, P. R. B., Fonseca, F. C. P., Cesar Netto, C., Carvalho, K. C., Soares Junior, J. M., … Godoy-Santos, A. L. (2018). ERα PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study. J Orthop Surg Res, 13(1), 316. https://doi.org/10.1186/s13018-018-1020-x
Pontin, P. A., P. R. B. Nogara, F. C. P. Fonseca, C. Cesar Netto, K. C. Carvalho, J. M. Soares Junior, E. C. Baracat, et al. “ERα PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study.J Orthop Surg Res 13, no. 1 (December 11, 2018): 316. https://doi.org/10.1186/s13018-018-1020-x.
Pontin PA, Nogara PRB, Fonseca FCP, Cesar Netto C, Carvalho KC, Soares Junior JM, et al. ERα PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study. J Orthop Surg Res. 2018 Dec 11;13(1):316.
Pontin, P. A., et al. “ERα PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study.J Orthop Surg Res, vol. 13, no. 1, Dec. 2018, p. 316. Pubmed, doi:10.1186/s13018-018-1020-x.
Pontin PA, Nogara PRB, Fonseca FCP, Cesar Netto C, Carvalho KC, Soares Junior JM, Baracat EC, Fernandes TD, Maffulli N, Santos MCL, Godoy-Santos AL. ERα PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study. J Orthop Surg Res. 2018 Dec 11;13(1):316.
Journal cover image

Published In

J Orthop Surg Res

DOI

EISSN

1749-799X

Publication Date

December 11, 2018

Volume

13

Issue

1

Start / End Page

316

Location

England

Related Subject Headings

  • Postmenopause
  • Posterior Tibial Tendon Dysfunction
  • Polymorphism, Single Nucleotide
  • Orthopedics
  • Middle Aged
  • Humans
  • Genetic Association Studies
  • Female
  • Estrogen Receptor alpha
  • Cross-Sectional Studies