A divide-and-conquer method for sparse risk prediction and evaluation.

Divide-and-conquer (DAC) is a commonly used strategy to overcome the challenges of extraordinarily large data, by first breaking the dataset into series of data blocks, then combining results from individual data blocks to obtain a final estimation. Various DAC algorithms have been proposed to fit a sparse predictive regression model in the $L_1$ regularization setting. However, many existing DAC algorithms remain computationally intensive when sample size and number of candidate predictors are both large. In addition, no existing DAC procedures provide inference for quantifying the accuracy of risk prediction models. In this article, we propose a screening and one-step linearization infused DAC (SOLID) algorithm to fit sparse logistic regression to massive datasets, by integrating the DAC strategy with a screening step and sequences of linearization. This enables us to maximize the likelihood with only selected covariates and perform penalized estimation via a fast approximation to the likelihood. To assess the accuracy of a predictive regression model, we develop a modified cross-validation (MCV) that utilizes the side products of the SOLID, substantially reducing the computational burden. Compared with existing DAC methods, the MCV procedure is the first to make inference on accuracy. Extensive simulation studies suggest that the proposed SOLID and MCV procedures substantially outperform the existing methods with respect to computational speed and achieve similar statistical efficiency as the full sample-based estimator. We also demonstrate that the proposed inference procedure provides valid interval estimators. We apply the proposed SOLID procedure to develop and validate a classification model for disease diagnosis using narrative clinical notes based on electronic medical record data from Partners HealthCare.

Duke Scholars

Author Chuan Hong Biostatistics & Bioinformatics, Division of Translational Bi ...