FIGURE 4 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

<p>PRC2 complex expression in ONB. <b>A,</b> PRC2 transcripts in the core complex are mostly upregulated in high-grade ONB. <b>B,</b> EPOP expression is significantly increased in high-grade ONB compared with low grade, with no differences between low and high grade in proteins that form the PRC2.2 complex. For A and B, statistical significance assessed by Kruskal–Wallis test with <i>post hoc</i> Dunn test for multiple comparisons (*, <i>P</i> < 0.05; **, <i>P</i> < 0.01). <b>C,</b> EZH2 is present in basal cells and immature neurons (TUJ1⁺) but not in mature neurons (OMP⁺) in the normal human OE. <b>D,</b> Immunohistochemically, Ki-67⁺ cells are nearly uniformly positive for EZH2 and EED in a grade I ONB. Scale bars in C and D are 50 μm.</p>

Duke Scholars

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