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FIGURE 3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

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Finlay, JB; Abi Hachem, R; Jang, DW; Osazuwa-Peters, N; Goldstein, BJ
June 6, 2023

<p>Patterns of gene expression in the normal differentiating OE. <b>A,</b> Trajectory UMAP depicting differentiation states across pseudotime, in seven normal olfactory mucosa biopsies scRNA-seq from Durante and colleagues, 2020 and Oliva and colleagues, 2021 (<a href="#bib13 bib24" target="_blank">13, 24</a>). <b>B,</b> Heat map showing canonical cell type–specific markers for selected OE cell stages. <b>C,</b> Schematic showing that the core PRC2 protein complex can combine with either EPOP+MTF2 to form PRC2.1 or with JARID2+AEBP2 to form PRC2.2. <b>D,</b> Heat map showing PRC2 gene expression (and IDH2). (HBC: horizontal basal cell; GBC: globose basal cell; INP: immediate neuronal precursor; iOSN: immature olfactory sensory neuron; mOSN: mature olfactory sensory neuron; PRC2: Polycomb repressive complex 2).</p>

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June 6, 2023
 

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Finlay, J. B., Abi Hachem, R., Jang, D. W., Osazuwa-Peters, N., & Goldstein, B. J. (2023). FIGURE 3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma. https://doi.org/10.1158/2767-9764.23302010.v1
Finlay, John B., Ralph Abi Hachem, David W. Jang, Nosayaba Osazuwa-Peters, and Bradley J. Goldstein. “FIGURE 3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma,” June 6, 2023. https://doi.org/10.1158/2767-9764.23302010.v1.
Finlay JB, Abi Hachem R, Jang DW, Osazuwa-Peters N, Goldstein BJ. FIGURE 3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma. 2023.
Finlay, John B., et al. FIGURE 3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma. 6 June 2023. Crossref, doi:10.1158/2767-9764.23302010.v1.
Finlay JB, Abi Hachem R, Jang DW, Osazuwa-Peters N, Goldstein BJ. FIGURE 3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma. 2023.

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Publication Date

June 6, 2023